DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and slc22a7b.3

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_001337264.3	Gene:	slc22a7b.3 / 100001772	ZFINID:	ZDB-GENE-131120-103	Length:	546	Species:	Danio rerio

Alignment Length:	557	Identity:	138/557 - (24%)
Similarity:	256/557 - (45%)	Gaps:	53/557 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYV---FTASTVVHRCTVPQCDSP---SSVYEED 99
            ::..|..|||:|   .::||:..:........::   |.|:...|.|.:...|:.   .::.||:
Zfish     6 LITEINGFGRFQ---KMILCISFVGRFIIPCHFLLSNFIAAIPSHHCDISFLDADGLFGNLTEEE 67

  Fly   100 WLGFTIP-KKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSE----TCGRDFKFRDEE 159
            .|..::| :::.:...||.           ::.|..|..:..  :.:|:    .|...:.|.:..
Zfish    68 RLIVSVPTQEDGSPVSCHM-----------FSHPQFQLLINS--SSSSDLPVVECQNGWHFDNST 119

  Fly   160 --KTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAV---AGSVSALMGV 219
              .|::|::.:.|::......|.||..||...|....|..:||:||:.||.|   :|...||..|
Zfish   120 FISTLATQWDLVCDNRGLNKAVATIFFVGVMFGAAFFGGMSDRFGRKPMLLVSYISGMAFALASV 184

  Fly   220 IRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLAS 284
               .|::::||.|..|......:.:...:.:|.:|.|..:.|...:.|.::.:|:|...|..:|.
Zfish   185 ---FSTSFTMFAVLRFFSGFTITGIVIVSSVLNLEWVDIEHRRLVSIIDSMAWAVGSTSLALIAY 246

  Fly   285 QVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKA------SNVLRRAARINQRPLPE 343
            .::.||||...:.:|.||..:..|.:|||.|||::.|..|||      ..|:.|.|.:..|..||
Zfish   247 FIRDWRWLTVAVTSPLVLCTILWWWVPESARWLIANGDVEKAHYYLHKCAVMNRKAEVTSRIKPE 311

  Fly   344 EQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGNKYT 408
            .....:....::|.:..:..:.|.||.:...:..:      ||....:..|:|||....|.|.|.
Zfish   312 ALAISVSDQGKKKYTYLDLVRTPKMRKLAMLTGTV------WFCVATMTYGISLNITGFGLNMYL 370

  Fly   409 NFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAI 473
            ...:.|.|::|..|:...:::::|||.:...:.|...|.:..:..:|.|.:.|...:.::||...
Zfish   371 TQFVYGAIEVPSKLIVYYLLEKIGRRKTEAGAQLFAGISLMINIFIPKDQWIGRTVVAVLGKGFA 435

  Fly   474 TCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGF 538
            ..:|..:..::||::||.:|...:...|.:.|:|..:||...||..::....|.:..:.|||:..
Zfish   436 VAAFCTIVLYSSELYPTVLRQNGMGYNSFLARLGVSVAPLVLLLDTFWGQFSQTILCSVALIASV 500

  Fly   539 LTLAFPETADKVLPTTIEEAR------DLNQAKRRSE 569
            :....|||.|:.||.|||:..      :.:|.|:.:|
Zfish   501 VAWNLPETRDRCLPETIEDVEGTGKTPNKDQEKQENE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	131/529 (25%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	103/391 (26%)
slc22a7b.3	XP_001337264.3	2A0119	12..516	CDD:273328	131/528 (25%)
slc22a7b.3	XP_001337264.3	MFS	141..506	CDD:119392	100/373 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010