DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and slc22a5

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	554	Identity:	160/554 - (28%)
Similarity:	264/554 - (47%)	Gaps:	39/554 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DEDNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYE 97
            |||.:.      :||.|.:.|..:.||.:..:......:..||.|::..|||.|      .....
Zfish     5 DEDTAF------LGQTGPFFIRLFCLLNLIYISTGLHGLYIVFVAASPAHRCRV------DVNLT 57

  Fly    98 EDWLGFTIPKKNSAWDD-----CHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRD 157
            ||||..:.|.:..:..|     |.||:......:||.....||..:.:   |..|.|...:.:..
Zfish    58 EDWLEASAPTETLSNGDLQVSQCWRYSLQTLTNLSGQGYSPGQINITD---IPRERCEDGWVYSA 119

  Fly   158 E--EKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVI 220
            :  ..||.:|:.:.|:.||::.:..:...:|..:|..:.|..:||:||:.:|..:.:..||:...
Zfish   120 DVYHSTIVSEWDLVCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGRKKVLFGSLAAEALLMFA 184

  Fly   221 RSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATI-ITIFYALGEAFLGFLAS 284
            :|.|.::.:|.|..|...|...:|:.|||:|..|::....||...|: ..:.|.:|...|.::|.
Zfish   185 QSFSPSWLIFCVLYFFIGAFQISLYITAFVLGNEVLSGSLRVLFTTLGAFLHYCVGYMLLPWVAF 249

  Fly   285 QVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDL 349
            .::|||.|||||....|:.|...|::|||.|||||||..:::..:||.|||.|:.|.||...
Zfish   250 AIRHWRTLLRVLSGLTVVYIPLWWLIPESPRWLLSQGHVQESEAILRDAARKNRVPAPEVIF--- 311

  Fly   350 LTSNRQKLSQANESQYPIMRAVVFFSLRIAN-------CCLCWFTHTLIALGLSLNSVNLGGNKY 407
                  |.||..|:.:...:......||.:|       |.|.|....:...|||||:.||.|:.:
Zfish   312 ------KQSQIKEAAFQKSKYSALDVLRTSNIRRTTFMCLLLWMAINIGYFGLSLNTTNLSGDPF 370

  Fly   408 TNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLA 472
            .|..|:...::|..::...::....||..|.|.:::....:.....:|......:|||.:.||..
Zfish   371 LNCFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFLVIGGGFLLLVQLIPDRLQTLALALEMAGKFG 435

  Fly   473 ITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISG 537
            .|.||.::|.:|:|::||.:||..:.:||...||||:.||....|..:..:.|.:|..:..:.:.
Zfish   436 FTMSFTVVYIYTAELYPTVLRNLGMGMCSSAARIGSITAPYIIFLGTFNRHLPYVLMGSLTITAS 500

  Fly   538 FLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571
            ...|..|||..||||..:|:.:.......|.::|
Zfish   501 LANLFLPETFGKVLPENLEQMQKSRSFPGRDKQS 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	154/522 (30%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	118/390 (30%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	153/521 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020