Protein Alignment CG14562 and Hps3

DIOPT Version :10

• Sequence 1: NP_649372.1
• Gene: CG14562 / 40439
• FlyBaseID: FBgn0037142
• Length: 1536
• Species: Drosophila melanogaster
• Sequence 2: XP_008759090.1
• Gene: Hps3 / 310288
• RGDID: 1310548
• Length: 1034
• Species: Rattus norvegicus
• Alignment Length: 1018
• Identity: 195/1018 - (19%)
• Similarity: 356/1018 - (34%)
• Gaps: 292/1018 - (28%)

  Fly    74 ESTTTAGDERTPSRSTLATVGEVVQLIYCEAGKYLLTLEKEQAGSPVHSSSTISCTSSSNSNTVC 138
            |:....|.|.:..|.|.:|:|.|:::.|.|||.||:.:|
  Rat    42 EAFAVQGAELSRQRCTFSTLGRVLRMAYSEAGDYLVAIE-------------------------- 80

  Fly   139 SEDDTKMFVRIYANFWKFPDSRLNELPITIRIASMTTPKTPLVES----IDVIELPLRSPPELVQ 199
             |.:..:|:|.|.| |:  ..|.:...:.||:..... :....||    :.:||:|:...|..:.
  Rat    81 -EKNKTVFLRAYVN-WR--SKRNDNSRVCIRMVGHKM-EASFCESFRDQMSIIEMPMSEAPLCIS 140

  Fly   200 CCQTSGNIIVSSRDRIYLYEYTQCVHENTQPRFAFIDFLPFKFFVQLNFVPVRLCLAENVIACLS 264
            ||...|:::|....::.|:...   ::.....|:.::|.........|..||.:......:|.::
  Rat   141 CCPVKGDLLVGCTKKLVLFTLK---YDVVNEEFSMLNFERSLIIHINNITPVEISFCVGYVAVMA 202

  Fly   265 NRYCVAFKVVDALTSRASGGQDVSCLDNDYVGGDEPLSESLSLGSKASASGAGGGVVSSSHSQQS 329
            :...:..|                 |::|.:.|:                    ||  :.|.|:|
  Rat   203 DLEVLLLK-----------------LESDPIHGE--------------------GV--NHHPQES 228

  Fly   330 CDSDSLQSTSSAKPQVVMNGALPGRSPLDFNVAKLVNNAYGREFEPELRSQWDETTDYGAGKGQD 394
            .                        :||                        ::|.|......|.
  Rat   229 I------------------------NPL------------------------EQTEDVSNETSQL 245

  Fly   395 DNLDITISPQ---------RASDIKIKLVNEAKAMNVRGISGSSHLDDASVQY-DVRKLLQICMK 449
            ::.|..|..:         :.|.|.:||             .|:.|:|..|:| .|:.||.....
  Rat   246 ESEDFVICLKPLELFGEKCKQSGISVKL-------------ESTGLEDEKVKYLHVQHLLYRRFA 297

  Fly   450 TSENQPRVLDIFR--CMDLKAIYQRNSQEVDQEDDEYDMG-NQQVPSAVTTFKHVNRRTLKSSQH 511
            ...:...:.|..:  .:.|..|:|...     ..||.|:. .::|||....|         |..|
  Rat   298 PDISFYGLSDNIKLHSLQLLPIHQTGF-----HPDEKDLSQKKEVPSLFCFF---------SLPH 348

  Fly   512 QRCIGHALLVASSVDGFLYQFSAQGKWYSENEKPVASYSFTAPVIQVHINDYVVYAVTSESVETH 576
               .|:..:|..||. .|..:     ||.|..:            |..:....::.:||:|::..
  Rat   349 ---AGYLYMVVKSVT-LLSVY-----WYPEKSQ------------QAVLTPQFLHVITSQSLQCF 392

  Fly   577 TSRIGHKLFHNRFEYPSIGGLFPEESAPDVSSPIAVVGLAAFMHVQFVCVNREQLVLITNAALEQ 641
            |.|....:.|....|...    ..::.|.||..:..:.:..|:.::.:|..:..::|:|.|..|
  Rat   393 TVRCSAAVAHEEDLYMDT----TLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPE- 452

  Fly   642 HKRRSMSEVPGTQVVAVKRNIAARLLAEAKAKHNSLLRSSSAVQSST--VANE-WTLYNLEVPRV 703
                   ::|      .:|....|||:          |..::|:|..  ||.. |.||.:.....
  Rat   453 -------DIP------ERRESPKRLLS----------RKDASVKSRIPHVAEAGWNLYIVNTTAP 494

  Fly   704 ECVIEDLEGIAESYRSASSSNFFDLMEEAHVMLRISLTLQGERLGAEREQLLRKMFMANCRKLAD 768
            ..:.:::...:.||::..:.:...|:.|||:::|.:|....:...||:.:|| :.|..:|..|.|
  Rat   495 VQLYKEMVDYSNSYKTVKTESCLHLLSEAHLLVRAALMDVSQLEPAEKAELL-EAFKESCGHLGD 558

  Fly   769 FSIRSSKKEVYLQATGFYRMCQFHLVDIF-------NNYVQNFMDTEESVIPLELSGLIYTVKLF 826
            ...|.:.::.:| |..:|:|....|.::.       .|..|.:.           .|||:.:. .
  Rat   559 CYSRLNTEQAHL-ALPYYKMSGLSLAEVLARVEWTEGNESQKYE-----------RGLIFYIN-H 610

  Fly   827 LLCLGTDRLKSAFLNQTVLPYFTPARVIQQGYKQVPISLEFLNMFIKHAPLEIAQIMLVSPVVAD 891
            .|....|...|..|...|...|..|..     ||:|           |. |....:..:.|::|
  Rat   611 SLYENLDEELSEELAGKVAQIFHVAEP-----KQLP-----------HV-LSSPSMKNIDPLIA- 657

  Fly   892 SISGELINYLKYLDKLSPDE---NLLLAVTACRMSNYLLAQEVVSKSTRRNLATALIRHKNVLFD 953
                  ::||:.||......   .|..|..|.:|.|..:.:..:...:...|....|....:|
  Rat   658 ------LHYLRKLDTCGASPVLVTLTKAAVALKMGNLDMYRNEMKSHSEMQLVYGFILEPRLL-- 714

  Fly   954 DSTVIYQRRNQQQADSQALSLRARKSRRMAAK----SKPAPVGTPAPSTIVSFSDFCETILLANE 1014
                |.|.:.|......|:.|:..:...:.|.    .|...:|       :..:|....:|...:
  Rat   715 ----IQQWKGQIVPTELAIDLKETQPGLLVASVLGLQKNGKIG-------IEEADSFFKVLCGKD 768

  Fly  1015 Q---PALLEAISDAFIHALCIEHSMTLDVIL-QLFLNYIASHI 1053
            :   |.||....:|.:.| |:.     ||:| :||...|:.::
  Rat   769 EDMVPQLLVDFWEAQLVA-CLP-----DVVLEELFFKLISQYV 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14562	NP_649372.1	HPS3_N	3..274	CDD:464300	42/203 (21%)
		HPS3_Mid	<527..828	CDD:464301	61/310 (20%)
Hps3	XP_008759090.1	HPS3_N	3..212	CDD:464300	42/220 (19%)
		HPS3_Mid	255..640	CDD:464301	98/479 (20%)
		HPS3_C	649..960	CDD:464302	36/183 (20%)