Protein Alignment PolH and REV1

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_014991.1
• Gene: REV1 / 854527
• SGDID: S000005873
• Length: 985
• Species: Saccharomyces cerevisiae
• Alignment Length: 664
• Identity: 130/664 - (19%)
• Similarity: 221/664 - (33%)
• Gaps: 234/664 - (35%)

  Fly     7 HVSMQNKYDRVVLLVDMDCFF------CQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARA 65
            :..:.:|...::..:|.||||      |:.......:::..|:.|.  :..:...|.:.||.||:
Yeast   347 YTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVC--HGTKNSDIASCNYVARS 409

  Fly    66 KGVTRHMRGDEAKDLCPE-IVLCQVPNIREKADTSKYRDAGKEVANVLQRFT--QLLERASVDEA 127
            .|:...|...:|:.:.|. |.|..:|...|     :::...:...:.|:|..  .|:...|:|||
Yeast   410 YGIKNGMWVSQAEKMLPNGIKLISLPYTFE-----QFQLKSEAFYSTLKRLNIFNLILPISIDEA 469

  Fly   128 YLDITETVNHRMQQMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQ 192
            .                 ...:.|..:.||
Yeast   470 V-----------------CVRIIPDNIHNT----------------------------------- 482

  Fly   193 NDLPAVRQSDIRLLIGASVAGEVRAAVKKET-GYECSAGIAHNKILAKLAAGMNKPNKQTI---- 252
            |.|            .|.:..|:|..:.:.| |...|.|.:.:.:||:||..|.|||...|
Yeast   483 NTL------------NARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKS 535

  Fly   253 --------------LP------LTETASLFDS----------LPVGKIK-GLGGKFGEVVC---- 282
                          ||      |:...|.|||          ..:..:| .:|.|.|..:.
Yeast   536 NLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQ 600

  Fly   283 -----ETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGCCKKFPG 342
                 |:|.|.:..:.|      ||||      :...:|:.||..:.:|........||
Yeast   601 GQDDEESLKILYDPKEV------LQRK------SLSIDINWGIRFKNITQVDLFIERGC------ 647

  Fly   343 RNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDID-GEEVASSRSTALRDYD 406
                       .:|.|..:|||....:..::..||.|...::..:.:. |...:.|||:.|
Yeast   648 -----------QYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRL---- 697

  Fly   407 QESIVRLSLDLIKANTKTFLR----PGSESALNNAIKFLGISVGKFETVSSGQNKL------QEM 461
              .|......:|....|:..|    |..|      ::.|.:...|...|....|:|      :.:
Yeast   698 --GIPTNEFGIIATEMKSLYRTLGCPPME------LRGLALQFNKLVDVGPDNNQLKLRLPFKTI 754

  Fly   462 FANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISANPLAAA 526
            ..|:|.:          .||:   :.|....:||:.:    ||.:       |..|:::|.|::
Yeast   755 VTNRAFE----------ALPE---DVKNDINNEFEKR----NYKR-------KESGLTSNSLSS- 794

  Fly   527 AGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQY-----------LKQQKKTGQ--- 577
                        |.|..|..|.|   :...|:..:|.|.::.           |:.|||..|
Yeast   795 ------------KKKGFAISRLE---VNDLPSTMEEQFMNELPTQIRAEVRHDLRIQKKIQQTKL 844

  Fly   578 ---QGSVTSREDSL 588
               |..:..||:||
Yeast   845 GNLQEKIKRREESL 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	94/485 (19%)
		zf_UBZ	705..736	CDD:465769
		zf_UBZ	805..832	CDD:465769
REV1	NP_014991.1	BRCT_Rev1	165..249	CDD:349351
		PolY_Rev1	315..735	CDD:176455	95/499 (19%)
		Rev1_C	875..981	CDD:213388