Protein Alignment PolH and Polh

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_109640.1
• Gene: Polh / 80905
• MGIID: 1891457
• Length: 694
• Species: Mus musculus
• Alignment Length: 815
• Identity: 266/815 - (32%)
• Similarity: 392/815 - (48%)
• Gaps: 171/815 - (20%)

  Fly    15 DRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAKD 79
            :|||.||||||||.|||::|:|..||:|.|||||..|:|||||||:|.|||.||||:|..|:||.
Mouse     6 NRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWADDAKK 70

  Fly    80 LCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQS 144
            |||:::|.||...|.||:.:|||:|..||..::..|. ::||||:||||:|:|..|..|:|::|.
Mouse    71 LCPDLLLAQVRESRGKANLTKYREASVEVMEIMSYFA-VIERASIDEAYIDLTSAVQERLQKLQG 134

  Fly   145 GAFALQP---QELVNTFAVGY---PSIGDYVNK--ITNRFANPYMDDERYQMSYDQNDLPAVRQS 201
                 ||   ..|.:|:..|.   |::.:.|.|  |..:....::|..       |:|.|.  ..
Mouse   135 -----QPISADLLPSTYIEGLPRGPTVEETVQKEAIRKQGLLQWLDSL-------QSDDPT--SP 185

  Fly   202 DIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSLP 266
            |:||.:||.:..|:|||::.:||::|||||:|||:|||||.|:||||:||::.......||..:|
Mouse   186 DLRLTVGAMIVEEMRAAIESKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMP 250

  Fly   267 VGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYS 331
            :.||:.||||.|..|.|.|||::||.:.:|:|..||..|.||||:||:.:.|||:.:.|.||...
Mouse   251 IRKIRSLGGKLGASVIEVLGIEYMGDLTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLP 315

  Fly   332 KSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVAS 396
            |:|||.|.|||:..:...:.:|.||.:|:.|:.:||.||..:|:|.|..:||..  ...|:...|
Mouse   316 KTIGCSKNFPGKTALATREQVQWWLLQLALELEERLTKDRNDNDRVATQLVVSI--RFQGDRRLS 378

  Fly   397 S--RSTALRDYDQESIVRLSLDLIKA--NTKTFLRPGSESALNNAIKFLGISVGKFETV------ 451
            |  |..||..||..   ::|.|...|  |..|   .|.::..:..:..|.:...||...
Mouse   379 SLRRCCALPRYDAH---KMSQDAFAAIRNCNT---SGIQTEWSPPLTMLFLCATKFSAAAPPACT 437

  Fly   452 ---------SSGQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQG 507
                     ||.|.|:.     .|:.:.|..|..|. :|    ..|:..|   .:.|||.   :.
Mouse   438 DITAFLSSDSSCQPKVP-----IASSETRTQGSGPA-VP----TSKEAAT---SLASFFQ---KA 486

  Fly   508 AKKEDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQ 572
            |||:..|                ..:||         .:.|....|:|.|        |...:..
Mouse   487 AKKQRMK----------------ETSFV---------PLNTATEKLSSKP--------SLVFQSS 518

  Fly   573 KKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQE 637
            :.||.|...  ::.||.:|                       .|:|::......|  |:|.|.|
Mouse   519 QTTGSQSFF--KQKSLLLQ-----------------------HTQLSNSAAPDPP--QASPAAQ- 555

  Fly   638 QDPNTLN----DSTGNDLYVETGIVPPTLTEDELKPSTSKRKFDE----------IESSVSNYKE 688
              |:.|.    ||..:|     |.|         ||.:||....|          ::|...|.:|
Mouse   556 --PSCLPAECVDSGPDD-----GAV---------KPVSSKAVSTEMNVAGDSPNVLDSPAYNSQE 604

  Fly   689 CYVEFAVPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKI 753
                  |....|:  ..:.|::|.:.:|  |..:..|.|:|||.||.::.    .:..|...|.|
Mouse   605 ------VTQRATE--DQVLCEKCDSLVP--VWDMPEHTDYHFALELQKSF----LQPCTSKPQAI 655

  Fly   754 SLKPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFR 788
            .......|::.|:..:.||.........::..||:
Mouse   656 PAVSPQGKRNPKSPSASSSKRLRPHGMQTLESFFK 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	186/438 (42%)
		zf_UBZ	705..736	CDD:465769	11/30 (37%)
		zf_UBZ	805..832	CDD:465769
Polh	NP_109640.1	PolY_Pol_eta	10..427	CDD:176456	186/439 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..598		10/46 (22%)
		zf_UBZ	612..642	CDD:465769	11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	651..694		8/40 (20%)
		PIP-box. /evidence=ECO:0000250|UniProtKB:Q9Y253	682..689		0/6 (0%)