DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-eta and Esco2

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_082315.3	Gene:	Esco2 / 71988	MGIID:	1919238	Length:	592	Species:	Mus musculus

Alignment Length:	440	Identity:	82/440 - (18%)
Similarity:	142/440 - (32%)	Gaps:	136/440 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 SGDEPGQLPKVEMEKKQK----QTDEFKMKSFFANYLQGAKK--------EDAKADGISANPLAA 525
            |||:|  :|.|....::|    :.::.|.||..|.|....|.        :::|.:.::..|:..
Mouse   124 SGDKP--IPSVTENIQRKPVCTKKNKKKQKSLTAKYQPNYKHIKSKSRNLKNSKPNQVTYKPVVD 186

  Fly   526 AAGA--PNKNFVEEYKHKLHAAVRTEGTV-------------LTSTPAEFKESFFSQYL------ 569
            ...:  |.||:.......|...::.:.|:             |...|.|.|.....:.|
Mouse   187 QENSCFPAKNYPNSPPRVLSQKIKPQVTLQGGAAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEG 251

  Fly   570 --------------------------KQQKKTGQQGS---VTSREDSLDVQELAEELDAIEADNS 605
                                      |.::|..:..|   |:|:|.:||..:...|       ||
Mouse   252 APEAKQIPKSLLVDEKSSVKVQNARSKNEEKLRKNPSGAVVSSKECNLDKHDFPSE-------NS 309

  Fly   606 KDFEEDTEEETEL----TSDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDE 666
            .|..:....|:..    .|..:..:||.|||                         |..|...:.
Mouse   310 LDENKTISPESVYPIFNVSSVNTKRPEEQSS-------------------------VGSTACTNF 349

  Fly   667 LKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCG-----ANIPDEVKSLQTHR 726
            ||.:...:..:..:::.....:..::....:..|.:     |..||     :|..||::.||.|
Mouse   350 LKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTV-----CKSCGMIYTASNPEDEIQHLQHH- 408

  Fly   727 DHHFAQELSRTLRSTER--EERTQSRQKISLKPTPPKKSKKTAGSGS------SSYSTAPPSNSI 783
             |.|.:.:.......||  .|....:..:.|...|....||......      ....|.|.....
Mouse   409 -HRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQTVPVCPDK 472

  Fly   784 TKFFR------------AKPTQE--QAPSDPQMNQCPECKAFIKCVDMPE 819
            ||.|.            |:|.::  :..|:|..::  ||....:|.|:||
Mouse   473 TKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASK--ECSRAWRCSDVPE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456
		zf_UBZ	705..736	CDD:408236	11/35 (31%)
		zf_UBZ	805..832	CDD:408236	6/15 (40%)
Esco2	NP_082315.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..294		4/26 (15%)
		zf-C2H2_3	371..410	CDD:290589	10/45 (22%)
		Acetyltransf_13	520..582	CDD:290591	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030