DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and poli

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001027479.2	Gene:	poli / 613070	XenbaseID:	XB-GENE-943046	Length:	742	Species:	Xenopus tropicalis

Alignment Length:	925	Identity:	193/925 - (20%)
Similarity:	344/925 - (37%)	Gaps:	264/925 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSARSHVSMQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQ-YNPWRGGGIIAVNYAARA 65
            |..||..|.    .||::.:|||||:.|||..::||.||:||.:.| |.      ::..||.||.
Frog    40 SVGRSGTSA----SRVIVHIDMDCFYAQVEMIRNPELRNKPLGIQQKYI------VVTCNYEARK 94

  Fly    66 KGVTRHMRGDEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLD 130
            .|||:.|...:|::.||::||.      ...|.:.||:.......:|:.|:..:||...||.|:|
Frog    95 FGVTKLMLIKDAREKCPQLVLV------SGEDLTPYREMSYRATELLEEFSPQVERLGFDENYID 153

  Fly   131 ITETVNHRMQQMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDL 195
            :||.|:.::|:.:...              ..|.:..:|          |.|.:     .:.||
Frog   154 VTELVDKKLQEERGNG--------------RNPGVCGHV----------YSDQK-----MNVND- 188

  Fly   196 PAVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETAS 260
                .:.:|:..|:.:|.|:|||:....|....||.|.||:||||.:|.:|||:||.|.....:.
Frog   189 ----WAHVRIAAGSHIASEIRAALYNRLGLTGCAGTASNKLLAKLVSGTHKPNQQTALLHESHSH 249

  Fly   261 LFDSLP-VGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEA 324
            |.:||. |.:|.|:|.|..:.: |:||:..:..:.......|:::|.......:..:|||.|..|
Frog   250 LINSLDHVKRIPGIGYKTSKRL-ESLGLSRISDLQACPITLLEKEFGSSVAHRIQMLSRGEDDSA 313

  Fly   325 VTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDI 389
            |.|....:||.....|...:.:              ||:..::|:       |.::::|:..:
Frog   314 VVPSGPPQSISDEDSFKKCSTV--------------SEVKIKMEE-------RLRNLLVRISK-- 355

  Fly   390 DGEEVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESALNNAIKFLGISVG-KFETVSS 453
            ||.              ....:||::.....:.|.|.|...:..:.   ..:..::| :.:.|.:
Frog   356 DGR--------------IPHTLRLTIRQFSPSNKWFNRESRQCPIP---AHISQNIGAECQAVPA 403

  Fly   454 GQNKLQEMFANQAAKKRRVSGDEPGQLPKVEME-------------KKQKQTDEFKMKSFFANYL 505
            ....|..:|.               ::..|:|:             |....|     :|....||
Frog   404 LMELLMRLFE---------------KMIDVKMQFHLTLLNVCFSNLKASNST-----RSSIGFYL 448

  Fly   506 QGAKKEDAKADGISANPLAAAAGAPN---KNF-VEEYKHKLHAAVRTEG-----------TVLTS 555
                  ..||...:|.||..:..|..   ::| ::|.....|.|.::.|           |:|.:
Frog   449 ------TLKAPPAAATPLKGSTEAEQHTAESFPLKENSSAPHTAPQSVGQPTAPVPTNHHTMLET 507

  Fly   556 TPAEFKESFFSQY---LKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETE 617
            .|.......|||.   ::|:...||:.:..|...|:                            .
Frog   508 LPEGIDPEVFSQLPEEIQQEIIAGQRHAAASSSSSV----------------------------R 544

  Fly   618 LTSDTHMSKPEG--------QSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKPSTSKR 674
            ..|.:..:.|:|        :::|...:.|...|.:.:                      .|::.
Frog   545 SASKSQAAPPKGILNFFSRAKAADLPSQCDGVLLKEHS----------------------QTNRG 587

  Fly   675 KFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQELSRTLR 739
            ..:..:.:.||:         |....|:.||       .::.|..:.:     |.|.|..
Frog   588 STEAPQGASSNF---------PKGVVDVRPT-------GSLWDPKQEM-----HPFGQSY----- 626

  Fly   740 STEREERTQSRQKISLKPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAPSDPQMNQ 804
                 :..||.::......|    ..:..|.|:|....||.::..:..:|...||:||
Frog   627 -----DTDQSAERCGTTAEP----MDSCCSSSTSCGQLPPQSAEMECAKAGGDQERAP------- 675

  Fly   805 CPECKAFIKCVDMPEHLDYHVARNLQRELNQQDLRTRTAALNKEKISPVQPKKQSQKKLNSTISA 869
                        .|..:|.:|...|..|: |::|......|......||:.:.:..|......:.
Frog   676 ------------FPHSVDVNVFSQLPEEV-QRELMAEWKQLKPTPKIPVRKQSEKAKASRGKRTG 727

  Fly   870 SSSGTKTIAQFFSQS 884
            :|:|..::.::|..|
Frog   728 ASAGASSLLKYFKPS 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	110/429 (26%)
		zf_UBZ	705..736	CDD:408236	5/30 (17%)
		zf_UBZ	805..832	CDD:408236	4/26 (15%)
poli	NP_001027479.2	PolY	53..433	CDD:330231	115/481 (24%)
poli	NP_001027479.2	DUF4414	<492..>534	CDD:316865	9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920