DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and poli

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001017834.1	Gene:	poli / 550532	ZFINID:	ZDB-GENE-050417-376	Length:	710	Species:	Danio rerio

Alignment Length:	833	Identity:	188/833 - (22%)
Similarity:	329/833 - (39%)	Gaps:	197/833 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SARSHVSMQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQ-YNPWRGGGIIAVNYAARAK 66
            |:...||:.::  ||:|..|:|||:.|||..::|..|.:||.:.| |.      |:..||.||..
Zfish    26 SSTDRVSLTSQ--RVILHFDLDCFYAQVEMIRNPALRTKPLGIQQKYI------IVTSNYVAREL 82

  Fly    67 GVTRHMRGDEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDI 131
            ||.:.|...:|.:.||::||.      :..|.:.||:...:|..:|..:..|:||...||.::|:
Zfish    83 GVNKLMSVTDAVEKCPQLVLV------KGEDLTHYREMSYKVTELLMSYCPLVERLGFDENFMDV 141

  Fly   132 TETVNHRMQQMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLP 196
            ||.|..|:::                            .:|::...|.::        |:...:
Zfish   142 TEMVEKRIKE----------------------------TRISDLSFNGHV--------YNHESV- 169

  Fly   197 AVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASL 261
            .|.:.:|||.:|:.:|.|:|.|:....|....||:|.||:||||.:|..|||:||.|.....|.|
Zfish   170 VVDEENIRLAVGSVIAAEMRQAIFSTLGLTGCAGVASNKLLAKLVSGSFKPNQQTTLLPHSNAEL 234

  Fly   262 FDSLP-VGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAV 325
            ..||. :.|:.|:|.|..|.: :.||:..:..:..:...||.::|.|.|...:.|::.|||...|
Zfish   235 MSSLTGLIKVPGIGYKTREKL-KALGLVNVRDLQLYPLSDLVKEFGEMNAKRVQNLACGIDDSPV 298

  Fly   326 TPRFYSKSIGCCKKFPGRNNITGLKTLQHWL---GELSSEINDRLEKD--------------FIE 373
            ||      .|..:.....::...:.||:..|   .||...:.:|:.||              .:.
Zfish   299 TP------AGPPQSLSDEDSFKKMSTLEEVLKKIEELLINLTERMHKDGRQPHTLRLTIRKYTVT 357

  Fly   374 N---NRRAKHMVVQYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESALN 435
            |   ||.::...   :.:..|.::....|.|:     ..::.||:.|.    ...:.|.....|.
Zfish   358 NRWFNRESRQCP---IPNHTGLKITGGSSEAV-----PQLLSLSMKLF----HKMVDPHQPFHLT 410

  Fly   436 NAIKFLGISVGKFETVSSGQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSF 500
                .|.:.....:..||.::.:...|.:::....::    |.|           |.|....:|.
Zfish   411 ----LLNVCFSNLQAKSSSKSSIASFFTHKSPSTTQI----PSQ-----------QVDSDLCESV 456

  Fly   501 FANYLQGA---KKED-------------AKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTE 549
            .:::...|   .|.|             .:....|.||.::.  :|.:...|   |..||.:...
Zfish   457 ASSHFTQADVLHKNDKAWKPVNNTSISPTQTQSTSVNPKSSL--SPRQPVSE---HSQHANINIR 516

  Fly   550 GTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEE 614
            ...|:|.|                ||.....:....|: ||.:|..|  .|:.:....|::.  :
Zfish   517 PPCLSSAP----------------KTTLHFKLPPNVDA-DVFKLLPE--HIQMELMSSFKKG--D 560

  Fly   615 ETELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKPSTSKRKFDEI 679
            .....:||....||.|.:.|.::  |.|                          |...:...:..
Zfish   561 SFYRPADTEDVDPEHQPTFASRQ--PKT--------------------------PKPCESAVNVC 597

  Fly   680 ESSVSNYKECYVEF----AVPNLRTDILPTIKCDQCGANIPDEVKSLQ----THRDHHFAQELSR 736
            .:|.||..|....|    ::|...::::...:.|    :||...:::|    .:.|.:...:|.
Zfish   598 TNSASNPHELSQNFSSPQSIPEFSSELVMVTESD----DIPHSTQAIQPEVPANVDPYVFSQLP- 657

  Fly   737 TLRSTEREERTQSRQKISLKPTPPKKSKKTAGSGSSSYST-APPSNSITKFFR 788
              ...:||..|:.||:..:...|.|.|.|::.|.....|| ....|:|.|:|:
Zfish   658 --ADVQRELLTEWRQQRPVLKIPSKHSHKSSNSRDRKTSTKGSQCNNILKYFK 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	114/448 (25%)
		zf_UBZ	705..736	CDD:408236	6/34 (18%)
		zf_UBZ	805..832	CDD:408236
poli	NP_001017834.1	PolY_Pol_iota	40..418	CDD:176457	115/449 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850