DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-eta and POLH

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_006493.1	Gene:	POLH / 5429	HGNCID:	9181	Length:	713	Species:	Homo sapiens

Alignment Length:	905	Identity:	263/905 - (29%)
Similarity:	401/905 - (44%)	Gaps:	230/905 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRG 74
            |....||||.||||||||.|||::|:|..||:|.|||||..|:|||||||:|.|||.||||.|..
Human     1 MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWA 65

  Fly    75 DEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRM 139
            |:||.|||:::|.||...|.||:.:|||:|..||..::.||. ::||||:||||:|:|..|..|:
Human    66 DDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFA-VIERASIDEAYVDLTSAVQERL 129

  Fly   140 QQMQSGAFALQP---QELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMS----------YD 191
            |::|.     ||   ..|.:|:..|.|.             .|...:|..|..          .|
Human   130 QKLQG-----QPISADLLPSTYIEGLPQ-------------GPTTAEETVQKEGMRKQGLFQWLD 176

  Fly   192 QNDLPAVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLT 256
            ...:..:...|::|.:||.:..|:|||:::|||::|||||:|||:|||||.|:||||:||::...
Human   177 SLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHG 241

  Fly   257 ETASLFDSLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGID 321
            ....||..:|:.||:.||||.|..|.|.|||::||::.:|:|..||..|.||||:||:.:.|||:
Human   242 SVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE 306

  Fly   322 LEAVTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYV 386
            .:.|.||...|:|||.|.|||:..:...:.:|.||.:|:.|:.:||.||..:|:|.|..:||..
Human   307 HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSI- 370

  Fly   387 QDIDGEEVASS--RSTALRDYDQESIVRLSLDLIK-ANTKTFLRPGSESALNNAIKFLGISVGKF 448
             .:.|::..||  |..||..||...:...:..:|| .||.     |.::..:..:..|.:...||
Human   371 -RVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTS-----GIQTEWSPPLTMLFLCATKF 429

  Fly   449 E-TVSSGQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTD------------EFKMKSF 500
            . :..|....:....::           :|..||||.:...:.:|.            ...::||
Human   430 SASAPSSSTDITSFLSS-----------DPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESF 483

  Fly   501 FANYLQGAKKEDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFF 565
            |....:..|.::|....::|...|..:.:|:|           .::..:.:..|.|...||:.
Human   484 FQKAAERQKVKEASLSSLTAPTQAPMSNSPSK-----------PSLPFQTSQSTGTEPFFKQK-- 535

  Fly   566 SQYLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQ 630
            |..|||                                                      |....
Human   536 SLLLKQ------------------------------------------------------KQLNN 546

  Fly   631 SSDAGQEQDPNTLNDSTGNDLYVE-TGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFA 694
            ||.:..:|:|.:...:..|.|..| .|.||                   :...||
Human   547 SSVSSPQQNPWSNCKALPNSLPTEYPGCVP-------------------VCEGVS---------- 582

  Fly   695 VPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKISLKPTP 759
                        |.::.....|.|:             :|:...:|......::|..:::.|.||
Human   583 ------------KLEESSKATPAEM-------------DLAHNSQSMHASSASKSVLEVTQKATP 622

  Fly   760 PKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAPSDPQMNQCPECKAFIKCVDMPEHLDYH 824
                              .||        ....::|.|       |.:|.:.:...|||||:|||
Human   623 ------------------NPS--------LLAAEDQVP-------CEKCGSLVPVWDMPEHMDYH 654

  Fly   825 VARNLQRELNQ---QDLRTRTAALNKEKISPVQPKKQSQKKLNSTISASSSGTKTIAQFF 881
            .|..||:...|   .:.:..:|..::.|.:|..|...:.|:      ....|.:|:..||
Human   655 FALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKR------PRPEGMQTLESFF 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	183/442 (41%)
		zf_UBZ	705..736	CDD:408236	4/30 (13%)
		zf_UBZ	805..832	CDD:408236	13/26 (50%)
POLH	NP_006493.1	DinP	7..>354	CDD:223466	165/365 (45%)
		PolY_Pol_eta	10..428	CDD:176456	183/443 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..472		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..527		5/42 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..705		6/33 (18%)
		PIP-box. /evidence=ECO:0000269\|PubMed:15149598, ECO:0000269\|PubMed:16357261	701..708		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158675
Domainoid	1	1.000	194	1.000	Domainoid score	I3180
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2308
Isobase	1	0.950	-	0	Normalized mean entropy	S4070
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	1	1.000	-	-		oto89863
orthoMCL	1	0.900	-	-		OOG6_102732
Panther	1	1.100	-	-	LDO	PTHR45873
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	1	1.000	-	-		X4768
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740