DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and POLK

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001374040.1	Gene:	POLK / 51426	HGNCID:	9183	Length:	884	Species:	Homo sapiens

Alignment Length:	929	Identity:	214/929 - (23%)
Similarity:	351/929 - (37%)	Gaps:	246/929 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAV----NYAARAKGVTRHMRGDEAK 78
            ::.:|||.|:..||.:.:||.:::|:||         |.:::    ||.||..||...|.|..||
Human   103 IVHIDMDAFYAAVEMRDNPELKDKPIAV---------GSMSMLSTSNYHARRFGVRAAMPGFIAK 158

  Fly    79 DLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQ--- 140
            .|||::::.. ||.      .|||...|||..:|..:.......|:|||||:||:.:..|..
Human   159 RLCPQLIIVP-PNF------DKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPE 216

  Fly   141 -------QMQSGAFALQPQELVN-------TFAVGYPSIGDYVNKIT--NRFANPYMDDER---- 185
                   :|.|..    ..:|.|       ||.   .:.|..|||::  .|..:|.:.:|.
Human   217 DKRRYFIKMGSSV----ENDLQNLYIQRSITFT---DNPGKEVNKLSEHERSISPLLFEESPSDV 274

  Fly   186 ------YQMSYDQNDLPAVRQSDIRLLIGAS---VAGEVRAAVKKETGYECSAGIAHNKILAKLA 241
                  :|:::::.:.|.:.|:.:  :.|.|   |..|:|..::::|....|||||.|.:|||:.
Human   275 QPPGDPFQVNFEEQNNPQILQNSV--VFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVC 337

  Fly   242 AGMNKPNKQ-TILPLTETASLF-DSLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRK 304
            :..||||.| .|||..:....| ..||:.|:.|: ||..|.:.:.|||      :..:|:..||.
Human   338 SDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGI-GKVTEKMLKALGI------ITCTELYQQRA 395

  Fly   305 -----FDEKNGTWLFNISRGIDLEAVTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEIN 364
                 |.|.:..:..:||.|:....:|.....||:...:.|...|......:|   ..||.||:.
Human   396 LLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSL---CQELCSELA 457

  Fly   365 DRLEKDFIENNR-RAKHMVVQYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKANTKT-FLR 427
            ..|:|:.::... ..|...|.:........|:|..|||      |.|..::.:|:|..... |..
Human   458 QDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTA------EEIFAIAKELLKTEIDADFPH 516

  Fly   428 PGSESALNNAIKFLGISVGKFETVSSGQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQT 492
            |       ..::.:|:.:..|......:::.:.:.....|..:.:|..| ..|.|.:.:|..|..
Human   517 P-------LRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATE-CTLEKTDKDKFVKPL 573

  Fly   493 DEFKMKSFFANYLQGAKKEDAK---ADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLT 554
            :....||||     ..|:.:.|   .|.....       |.||...:                 |
Human   574 EMSHKKSFF-----DKKRSERKWSHQDTFKCE-------AVNKQSFQ-----------------T 609

  Fly   555 STPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQEL-------AEELDAIEADNSKDFEE-- 610
            |.|        .|.||  ||..:...::  |:|.|.|.|       |:...::||.| |..:|
Human   610 SQP--------FQVLK--KKMNENLEIS--ENSDDCQILTCPVCFRAQGCISLEALN-KHVDECL 661

  Fly   611 ---DTEEETELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKPSTS 672
               ...|..::.|.:|:|                                            :|.
Human   662 DGPSISENFKMFSCSHVS--------------------------------------------ATK 682

  Fly   673 KRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVK--SLQTHRDHHFAQELS 735
            ..|.:.:.:|....|:.|.  |.|.::.  :.::.|......|.:..|  |:....:.|..:|.|
Human   683 VNKKENVPASSLCEKQDYE--AHPKIKE--ISSVDCIALVDTIDNSSKAESIDALSNKHSKEECS 743

  Fly   736 RTLRSTEREERTQSRQKISLKPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAPSDP 800
                              ||    |.||........:|.||....|.....||.:..|      |
Human   744 ------------------SL----PSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQ------P 780

  Fly   801 QMNQ--------CPECKAFIKCVDMPEHLDYHVARNLQRELNQQDLRTRTAALNKEKISPVQPKK 857
            .:.:        ||.|....|..|: ...:.||...|.:...|:        |.|:|.:||...|
Human   781 YLCEVKTGQALVCPVCNVEQKTSDL-TLFNVHVDVCLNKSFIQE--------LRKDKFNPVNQPK 836

  Fly   858 QSQKKLNSTISASSSGTKT 876
            :|.:...|:.....:.|:|
Human   837 ESSRSTGSSSGVQKAVTRT 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	127/471 (27%)
		zf_UBZ	705..736	CDD:408236	6/32 (19%)
		zf_UBZ	805..832	CDD:408236	8/26 (31%)
POLK	NP_001374040.1	PolY_Pol_IV_kappa	104..530	CDD:176459	127/473 (27%)
		ZnF_Rad18	635..661	CDD:128973	7/26 (27%)
		zf-WRNIP1_ubi	790..816	CDD:383112	7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..872		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840