Protein Alignment PolH and Poli

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: XP_063133258.1
• Gene: Poli / 291526
• RGDID: 1305212
• Length: 788
• Species: Rattus norvegicus
• Alignment Length: 816
• Identity: 184/816 - (22%)
• Similarity: 306/816 - (37%)
• Gaps: 245/816 - (30%)

  Fly    16 RVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQ-YNPWRGGGIIAVNYAARAKGVTRHMRGDEAKD 79
            ||::.||:|||:.|||...:||.:::||.|.| |.      ::..||.||..||.:.|...:||:
  Rat    48 RVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYL------VVTCNYEARKLGVKKLMNVRDAKE 106

  Fly    80 LCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQS 144
            .||::||.      ...|.|:||:...:|..:|:.|:..:||...||.::|:||.|..|:||:.|
  Rat   107 KCPQLVLV------NGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPS 165

  Fly   145 GAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMS---YDQNDLPAVRQSDIRLL 206
                                  |.|..:|              ||   |:...:.....:.:||.
  Rat   166 ----------------------DEVPSVT--------------MSGHVYNNQSVNLHSSTHVRLA 194

  Fly   207 IGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSL-PVGKI 270
            :|:.:|.|:|.|:..:.|....||:|.||:||||.:|:.|||:||:|.......|..|| .:.::
  Rat   195 VGSQIAAEMREAMHNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEM 259

  Fly   271 KGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIG 335
            .|:|.|..:.: |.|||..:..:..|....|:::........:..:|.|.|...|||....:|..
  Rat   260 PGIGYKTAKRL-EVLGINSVHDLQTFPIKTLEKELGISVAQRIRKLSFGEDKSPVTPSGPPQSFS 323

  Fly   336 -------CCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEE 393
                   |..:...:..|..|         |||.:|.      :.::.|..|.:...::....:.
  Rat   324 EEDTFKKCSSEVEAKTKIEEL---------LSSLLNR------VCHDGRKPHTIRLVIRRYSDKH 373

  Fly   394 V-ASSRSTAL----------RDYD-----QESIVRLSLDLIKANTKTFLRPGSE-----SALNNA 437
            . ..||...:          .:||     .|.:::|..:::.......|...|.     .|||:|
  Rat   374 CNRESRQCPIPSHVIQKLGTGNYDAVPPLMEILMKLFRNMVNVKMAFHLTLLSVCFCNLKALNSA 438

  Fly   438 IK-----FLGISVGKFETVSSGQN--KLQEMFANQAAKK----------RRVSGDEPGQLPK-VE 484
            .|     ||..|:.  .|..||:.  |::::....:.|:          ||:.....|:.|. ..
  Rat   439 KKGPMDCFLTSSLS--TTACSGKRSFKVKDIHMEDSYKEKEANWDCLPSRRIESTRRGESPSDAT 501

  Fly   485 MEKKQKQTDEFKMK----------------SFFANYLQGAKKEDAKADGISANPLAAAAGAPNKN 533
            ...|:|.|.:..::                ......|.|..:|:.:..|..:.||.|:.|
  Rat   502 CFPKEKDTSDLPLQFLPEGVDQEVFTQLPADIQEEILSGKSRENLQGKGSLSCPLHASRG----- 561

  Fly   534 FVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQELAEELD 598
                              ||         ||||      .|..|.|.::.|
  Rat   562 ------------------VL---------SFFS------TKQTQAGCLSPR-------------- 579

  Fly   599 AIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLT 663
                            :|.||         |:.:.|....:|.|...||.:..:...|.......
  Rat   580 ----------------DTLLT---------GKQASAVSPCEPGTSGLSTSSSSHPSCGKDCSYYV 619

  Fly   664 EDELK-------PSTSKR-KFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVK 720
            :::||       |:.|:. .|.....:||      |..:.|||:::.|
  Rat   620 DNQLKDERMSQGPTESQGFHFSNTNPAVS------VFHSFPNLQSEQL----------------- 661

  Fly   721 SLQTHR--DHHFAQELSRTLRSTEREERTQSRQKIS 754
             ..|||  |.| .|..:.:.:..|..|:..:.:|::
  Rat   662 -FSTHRTADSH-KQTATTSHQGLENREQDSADEKLT 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	121/464 (26%)
		zf_UBZ	705..736	CDD:465769	6/32 (19%)
		zf_UBZ	805..832	CDD:465769
Poli	XP_063133258.1	None