DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and Polk

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_036178.1	Gene:	Polk / 27015	MGIID:	1349767	Length:	852	Species:	Mus musculus

Alignment Length:	875	Identity:	204/875 - (23%)
Similarity:	341/875 - (38%)	Gaps:	222/875 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAKD 79
            :..::.||||.|:..||.:.:||.:::|:||...:.     :...||.||..||...|.|..||.
Mouse    99 NNTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSM-----LATSNYHARRFGVRAAMPGFIAKR 158

  Fly    80 LCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQS 144
            |||::::.. ||.      .|||...|||..:|..:.......|:|||||:||:.:..|..
Mouse   159 LCPQLIIVP-PNF------DKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQD---- 212

  Fly   145 GAFALQPQELVNTFAVGYPSIGDYV---------NKIT--NRFANPYMDDER----------YQM 188
                 .|::....|.    .:|:|:         |::|  .|..:|.:.::.          :|:
Mouse   213 -----WPEDKRRYFI----KMGNYLKIDTPRQEANELTEYERSISPLLFEDSPPDLQPQGSPFQL 268

  Fly   189 SYDQNDLPAVRQSDIRLLIGAS---VAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQ 250
            :.::.:.|.:.|:.:  :.|.|   |..|:|..::::|....|||||.|.:|||:.:..||||.|
Mouse   269 NSEEQNNPQIAQNSV--VFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQ 331

  Fly   251 -TILPLTETASLF-DSLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRK-----FDEK 308
             .|||.......| ..||:.|:.|: ||..|.:...|||      |..:|:..||.     |.|.
Mouse   332 YQILPSRSAVMDFIKDLPIRKVSGI-GKVTEKMLMALGI------VTCTELYQQRALLSLLFSET 389

  Fly   309 NGTWLFNISRGIDLEAVTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIE 373
            :..:..:|:.|:....:......||:...:.|   :.|:..:.......||.:|:...|:|:.::
Mouse   390 SWHYFLHIALGLGSTDLARDGERKSMSVERTF---SEISKTEEQYSLCQELCAELAHDLQKEGLK 451

  Fly   374 NNR-RAKHMVVQYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESALNNA 437
            ... ..|...|.:........|.::.|||      |.|..::.:|:    :|.:..||...|.
Mouse   452 GRTVTIKLKNVNFEVKTRASTVPAAISTA------EEIFAIAKELL----RTEVNVGSPHPLR-- 504

  Fly   438 IKFLGISVGKFETVSSGQNKLQEMF-----ANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKM 497
            ::.:|:.:..|.:....:::.:.:.     .|||...   :||...:..|.|:.|..:.:.:
Mouse   505 LRLMGVRMSTFSSEDDRKHQQRSIIGFLQAGNQALSS---TGDSLDKTDKTELAKPLEMSHK--- 563

  Fly   498 KSFFANYLQGAKKEDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKE 562
            ||||      .||...:............||......:|.
Mouse   564 KSFF------DKKRSERISNCQDTSRCKTAGQQALQILEP------------------------- 597

  Fly   563 SFFSQYLKQQKKTGQQGSVTSREDSLDVQEL-------AEELDAIEADNSKDFE----EDTEEET 616
               ||.||:..:     |..:.|:|.|.|..       .:|..::||.|....|    ..|.|.:
Mouse   598 ---SQALKKLSE-----SFETSENSNDCQTFICPVCFREQEGVSLEAFNEHVDECLDGPSTSENS 654

  Fly   617 ELTSDTHMSKPE-GQSSDA----------GQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKPS 670
            :::..:|.|..: ||..|.          |.|....||.|  |.||   ||      |||.   |
Mouse   655 KISCYSHASSADIGQKEDVHPSIPLCEKRGHENGEITLVD--GVDL---TG------TEDR---S 705

  Fly   671 TSKRKFDEIESSVSNYKEC--YVEFAVP-NLRTDILPTIK-------------------CDQCGA 713
            ....:.|.:|::.|. :||  ..:.:.| :|..:.:.|:.                   |..|
Mouse   706 LKAARMDTLENNRSK-EECPDIPDKSCPISLENETISTLSRQDSVQPCTDEVVTGRALVCPVC-- 767

  Fly   714 NIPDEVKSLQTHRDH-------HFAQEL-----------SRTLRSTEREERTQSRQKISLKPTPP 760
            |:..|...|.....|       ...|||           ..:.|||:|.::...|.|     .|.
Mouse   768 NLEQETSDLTLFNIHVDICLNKGIIQELRNSEGNSVKQPKESSRSTDRLQKASGRTK-----RPG 827

  Fly   761 KKSKKTAGSGSSSYSTAP--PSNSITKFFR 788
            .|:|     .|:...|.|  |.:::..||:
Mouse   828 TKTK-----SSTLKKTKPRDPRHTLDGFFK 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	119/458 (26%)
		zf_UBZ	705..736	CDD:408236	10/67 (15%)
		zf_UBZ	805..832	CDD:408236
Polk	NP_036178.1	PolY_Pol_IV_kappa	103..513	CDD:176459	119/458 (26%)
		PRK02406	107..521	CDD:235035	118/462 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..273		1/20 (5%)
		ZnF_Rad18	620..645	CDD:128973	5/24 (21%)
		ZnF_Rad18	761..787	CDD:128973	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..852		14/63 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840