DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and Poli

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_036102.2	Gene:	Poli / 26447	MGIID:	1347081	Length:	737	Species:	Mus musculus

Alignment Length:	795	Identity:	192/795 - (24%)
Similarity:	312/795 - (39%)	Gaps:	189/795 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQ-YNPWRGGGIIAVNYAARAKGVTRHMRGDEAKD 79
            ||::.||:|||:.|||...:||.::|||.|.| |.      ::..||.||..||.:.|...:||:
Mouse    48 RVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYL------VVTCNYEARKLGVRKLMNVRDAKE 106

  Fly    80 LCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQS 144
            .||::||.      ...|.|:||:...:|..:|:.|:..:||...||.::|:||.|..|:||:
Mouse   107 KCPQLVLV------NGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQL-- 163

  Fly   145 GAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRLLIGA 209
                  |.|.|       ||:..:.:...|:..|.:....|                  ||::|:
Mouse   164 ------PSEEV-------PSVTVFGHVYNNQSVNLHNIMHR------------------RLVVGS 197

  Fly   210 SVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSL-PVGKIKGL 273
            .:|.|:|.|:..:.|....||:|.||:||||.:|:.|||:||:|.......|..|| .:.:|.|:
Mouse   198 QIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGI 262

  Fly   274 GGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGCCK 338
            |.|..:.: |.|||..:..:..|....|:::........:..:|.|.|...|||....:|.
Mouse   263 GYKTAKRL-EVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSF---- 322

  Fly   339 KFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVASSRSTAL- 402
                                  || .|..:|...|...:||.           ||:.||..|.:
Mouse   323 ----------------------SE-EDTFKKCSSEVEAKAKI-----------EELLSSLLTRVC 353

  Fly   403 RDYDQESIVRLSLDLIKANTKTFLRPGSESAL-NNAIKFLGISVGKFETVSSGQNKLQEMFAN-- 464
            :|..:...|||.:.  :.:.|...|...:..: ::.|:.||  .|..:::....:.|.::|.|
Mouse   354 QDGRKPHTVRLVIR--RYSDKHCNRESRQCPIPSHVIQKLG--TGNHDSMPPLIDILMKLFRNMV 414

  Fly   465 ---------------------QAAKKRRV-----SGDEPGQLPKVEMEKKQKQT-DEFKMKSFFA 502
                                 .:|||..:     |...|....|...:.|...| |..|.|....
Mouse   415 NVKMPFHLTLMSVCFCNLKALSSAKKGPMDCYLTSLSTPAYTDKRAFKVKDTHTEDSHKEKEANW 479

  Fly   503 NYLQGAKKEDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQ 567
            :.|...:.|   :.|...:||.|......|:..:.....|...|..|  |....||:.:|...|.
Mouse   480 DCLPSRRIE---STGTGESPLDATCFPKEKDTSDLPLQALPEGVDQE--VFKQLPADIQEEILSG 539

  Fly   568 YLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFE------EDTEEETELTSDTHMSK 626
              |.::....:||::.        .|......:...::|..:      .||...::..|.....:
Mouse   540 --KSRENLKGKGSLSC--------PLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCE 594

  Fly   627 PEGQSSDAGQEQDPNTLNDSTGND--LYVETGIVPPTLTEDELK---PSTSKR-KFDEIESSVSN 685
            |.......|....|     |.|.|  .|:::.:      :||..   |:.|:. :|.....:||.
Mouse   595 PGTSGLSPGSTSHP-----SCGKDCSYYIDSQL------KDEQTSQGPTESQGCQFSSTNPAVSG 648

  Fly   686 YKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVKSLQTHR--DHHFAQELSRTLRSTEREERTQ 748
            :      .:.|||:|:.|                  ..|||  |.| .|..:.:.:..|..:..:
Mouse   649 F------HSFPNLQTEQL------------------FSTHRTVDSH-KQTATASHQGLESHQGLE 688

  Fly   749 SRQKISLK---PTPP 760
            ||:..|.:   |.||
Mouse   689 SRELDSAEEKLPFPP 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	120/430 (28%)
		zf_UBZ	705..736	CDD:408236	6/32 (19%)
		zf_UBZ	805..832	CDD:408236
Poli	NP_036102.2	PolY_Pol_iota	51..431	CDD:176457	124/467 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850