DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and rev-1

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_495663.1	Gene:	rev-1 / 174275	WormBaseID:	WBGene00014066	Length:	1027	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	144/743 - (19%)
Similarity:	242/743 - (32%)	Gaps:	283/743 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SMQNKYDR--VVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRG------GGIIAVNYAARA 65
            |:.|:..|  .|..||:||||..|..:...:.:::.:|:...   :|      ..:.:.:||||.
Worm   429 SLSNEISRESTVFHVDLDCFFVSVAVRNRIDLKHKEVAITHS---KGTISNSMSEVASCSYAARD 490

  Fly    66 KGVTRHMRGDEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLD 130
            .||...|...:|...||::.|  :|...|     .|....:::..:|..:|..:...|.||.|::
Worm   491 CGVKNGMLVRDALQKCPQLTL--LPYQFE-----DYVQVSRKIYEILASYTLEVRAVSCDEMYIN 548

  Fly   131 ITETVNHRMQQMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDL 195
                                    :::|.                        |:|::    ||
Worm   549 ------------------------MSSFC------------------------EKYEI----ND- 560

  Fly   196 PAVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETAS 260
            |.:            :|..:|..::::|....|.||....:||:||....||:           .
Worm   561 PTI------------LAEHIRKVIREKTQCPASVGIGSTSLLARLATRHAKPD-----------G 602

  Fly   261 LF--------DSLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRK------FDEKNGT 311
            :|        :.:...|:|.|.| ||..:...| ..|.|.:.|..|:.|:.:      |..|..:
Worm   603 VFWVNAHKKNEFISEEKVKDLPG-FGYEMMNRL-TSFFGDITKCRELQLKTERELVPVFGPKLAS 665

  Fly   312 WLFNISRGI-----DLEAVTPRFYSKSIGC----CKKFPGRNNITGLKTLQHWLGELSSEINDRL 367
            .:....|||     |..|...|   ||:.|    ..:|..|..:..|.|      .:.:|:..:|
Worm   666 KILRQCRGIEEDPDDFWATHVR---KSVSCDINYGIRFTKRGEVIQLMT------AIGAELERKL 721

  Fly   368 EKDFIENNRRAKHMVVQYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKAN----TKTFLRP 428
                                 ||.:..|.|             :.|.|.:..||    |..|:..
Worm   722 ---------------------IDSKLTAGS-------------ITLKLMVRSANAPIQTSKFMGH 752

  Fly   429 G-----------------SESALNNAIKF-------------LGISVGKFET--VSSGQNKLQEM 461
            |                 .||..:.|:|.             :|::.||.::  .......:|||
Worm   753 GICDTFTKTCNLNVPTTRGESLTSEAMKLYAKVSPKVEDLRGVGVTCGKLKSKLKKDAATAVQEM 817

  Fly   462 FANQAAKKRRVSGDEP-GQLPKVEMEKKQKQ------TDEFKMKSF-------FAN--------- 503
            |...:........||. ..:|:.|.|..::.      |::.:::|.       .||
Worm   818 FGKTSRVGNMARTDEQLNIIPRNEDELDKEPVIIPAVTEDLEVQSIPRQINFRVANDIDIPEIVK 882

  Fly   504 --YLQG-----AKKEDAKADGISANPLA----AAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTP 557
              .|.|     .:.||.:.||:..|.||    .....|.|..|...:..|       .|:|....
Worm   883 STLLNGRSDNNLELEDLEDDGLVENRLAELECIIQNEPTKESVTNLQEML-------STLLNYGK 940

  Fly   558 AEFKESFFSQYLKQQKKTGQQGSVTS------------------REDSLDVQEL----AEELDAI 600
            ....|:.|.::        ::.|:.|                  .|:|.|:.|.    ...|.|:
Worm   941 LSAFETVFRKF--------EEISMDSSRCDTAWFSVFHLMVPFIEEESKDLLEFPIATTRNLGAM 997

  Fly   601 EADNSKDFEEDTEEETELTSDTHMSKPE 628
            .|.|              |.:|.:|.||
Worm   998 IASN--------------TDNTSISSPE 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	93/489 (19%)
		zf_UBZ	705..736	CDD:408236
		zf_UBZ	805..832	CDD:408236
rev-1	NP_495663.1	BRCT	251..326	CDD:278934
		PolY_Rev1	381..802	CDD:176455	98/503 (19%)
		DinP	440..809	CDD:223466	96/499 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810