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Protein Alignment DNApol-eta and ESCO2

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001017420.1	Gene:	ESCO2 / 157570	HGNCID:	27230	Length:	601	Species:	Homo sapiens

Alignment Length:	500	Identity:	96/500 - (19%)
Similarity:	163/500 - (32%)	Gaps:	128/500 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 YVQDIDGEEVASSRSTALRDYDQESIVRLSLDLI-------KANTKTFLRPGSESALNNAIKFLG 442
            |:..::.:.:..||||.|:..|::....:..:.:       |.|.|   :|..........|:..
Human    93 YLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNK---KPQKSLTAKYQPKYRH 154

  Fly   443 ISVGKFETVSSGQNKLQEMFANQAAKKRRV-SGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQ 506
            |......:.:|.||::  ::.....|:... |.:.....|:|..:|.:.|.......:||.....
Human   155 IKPVSRNSRNSKQNRV--IYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKS 217

  Fly   507 GAKK--------------------EDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGT 551
            ..:|                    ||:..:.:|.....|....| |..|.|.|.|:.
Human   218 SLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVP-KCLVLEEKLKIG-------- 273

  Fly   552 VLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEET 616
             |.|..::.||...        |......|:|:|..:|..|...             .||:..|.
Human   274 -LLSASSKNKEKLI--------KDSSDDRVSSKEHKVDKNEAFS-------------SEDSLGEN 316

  Fly   617 ELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGN-DLYVETGIVPPTLTEDELKPSTSKRKFDE-- 678
            :..|......|...:|....::.......|.|: :...:|.|...|.|.|     |||:..|:
Human   317 KTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRD-----TSKKTKDQLI 376

  Fly   679 IESSVSNYKECYVEFAVPNLRTDILPTIKCDQCG-----ANIPDEVKSLQTHRDHHFAQELSRTL 738
            |::...::.                .|: |..||     :|..||::.:|.|  |.|.:.:....
Human   377 IDAGQKHFG----------------ATV-CKSCGMIYTASNPEDEMQHVQHH--HRFLEGIKYVG 422

  Fly   739 RSTER--EERTQSRQKISLKPTPPKKSKKTAG-----SGSSSYSTAPPS--NSITKF-------- 786
            ...||  .|....:..:.|...|....||...     .....:....|.  |.|..|
Human   423 WKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKR 487

  Fly   787 ----FRAKPTQEQ--------APSDPQMNQCPECKAFIKCVDMPE 819
                ..|:|.::.        .|..|...:||  :|: :|.|:||
Human   488 VVGCLIAEPIKQAFRVLSEPIGPESPSSTECP--RAW-QCSDVPE 529

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.