Protein Alignment PolH and Rev1

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: XP_061501327.1
• Gene: Rev1 / 1276606
• VectorBaseID: AGAMI1_006519
• Length: 1180
• Species: Anopheles gambiae
• Alignment Length: 976
• Identity: 189/976 - (19%)
• Similarity: 312/976 - (31%)
• Gaps: 389/976 - (39%)

  Fly     2 SSARSH--VSMQNKYD-RVVLLVDMDCFFCQVEEKQHPEYRNRPLAV---------VQYNPWRG- 53
            :.||.|  ....|:.: |.::.:||||||..|..:::|..|..|:||         |..:|.:.
Mosquito   330 AGARDHPECDFSNESNARYIMHIDMDCFFVSVGLRKYPHLRGLPVAVTHSRGSEARVPSHPGQNR 394

  Fly    54 -----------------------------------GGIIAVNYAARAKGVTRHMRGDEAKDLCPE 83
                                               ..|.:.:|.||..||...|....|..||||
Mosquito   395 ALEIELYHKRLEERYKAPDIPIESRLAAIDEHNSLSEIASCSYEARQCGVKNGMFVGAALKLCPE 459

  Fly    84 IVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQSGAFA 148
              |..:|     .|...||:...::.:.:.|:|..:|..|.||.::|:|
Mosquito   460 --LKTIP-----YDFDGYREVAHQLYDTIARYTLDIEAVSCDEMFVDLT---------------- 501

  Fly   149 LQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRLLIGASVAG 213
                ||:.:..||......|
Mosquito   502 ----ELLQSTGVGVMEFVTY--------------------------------------------- 517

  Fly   214 EVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSLPVGKIKGLG---- 274
             ||..:...||.:|||||..|::.|::|....|||.|..|...........:|:.::.|:|
Mosquito   518 -VRNEISTATGCDCSAGIGANRLQARMATKRAKPNGQYHLVPGAVEEYMKVIPIAELPGVGPSTS 581

  Fly   275 ---GKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGC 336
               .|...|.|..|      |.:..:.  ||.:|.:|.|..|:|..||||   ..|..|.:
Mosquito   582 HRLRKMTYVTCADL------QTIPKNV--LQTEFGKKFGETLYNACRGID---ERPLVYDR---- 631

  Fly   337 CKKFPGRNNIT-----GLK-----TLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDG 391
                 ||.:::     |::     .:..::.:|:.||:.||    :|..:|.|.:.|:.:.....
Mosquito   632 -----GRKSVSVDVNYGIRFSTEQEVDRFMRQLTEEIHRRL----VELRQRGKLVTVKLLVRSPE 687

  Fly   392 EEVAS------------SRSTALRDY--DQESIVRLSLDLIKANTKTFLRPGSESALNNAIKFLG 442
            ..|.:            ::|..||.:  |:..|....|.|:    :|.....||      ::.:|
Mosquito   688 APVETAKFMGHGLCDVVTKSQPLRQHTDDRGMIEGAVLGLM----RTLAIAPSE------LRGIG 742

  Fly   443 ISVGKFETV-----SSGQNKLQEMFANQAAKKRRVSGDEPGQLPK------VEMEKKQ------- 489
            |.:.|||..     |...|:|:.||  |..:.:|...:|...:..      .|..::|
Mosquito   743 IQISKFEGTKHAANSEAGNRLKSMF--QKVEDKRKPAEETVTMVTNDGAMVAESSRQQHGAFYQP 805

  Fly   490 ----------------------------------------KQTDEFKMKSFFANY---------- 504
                                                    |:||.       |.|
Mosquito   806 DDQQPCTSRSNSAVQAIPPAVRQSYITPTKSDYSGPIISPKRTDN-------ATYSPSRKAAGAS 863

  Fly   505 ----------------LQGAKKEDAKAD---GISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEG 550
                            |.| :|:.||..   |:....|..|||:.:....|     |.|.:..|
Mosquito   864 KPSTRGRRGRPPKWASLSG-RKDPAKTTQSVGVMRKFLIGAAGSSSSGGGE-----LPAGLDPE- 921

  Fly   551 TVLTSTPAEFKESFFSQYLKQQKKTGQQ---------------------GSVTSRED-------- 586
             ||::.|.:.:|.....|.:||::..||                     ..||:|.:
Mosquito   922 -VLSALPEDIREEAIRDYRRQQQQQQQQLLATNNRLQPAVEKTPVKVSPARVTARREWQSPVTPQ 985

  Fly   587 ---SLDV---QELAEELDAIEA-----------------------DNSKDFEE------DTEEET 616
               |.|.   |::..:|..::|                       .|..:|||      |:....
Mosquito   986 HTASADTESDQKIKVDLKFLQALPLHLRLEVEKQIELNKDNMVVTCNEPEFEEPLLVTPDSSPAK 1050

  Fly   617 ELTSDTH----MSKPEGQSSDAGQEQDPNTLNDSTGNDL---YVETGIVP-----PTLTEDELKP 669
            ||.:.|.    .:.|:..|::  ..:|||.|......:|   ::.:...|     ..|.|:.|:.
Mosquito  1051 ELRTPTKGVVVAAAPDVASAE--PSRDPNILRRKNWRELVEEWINSAEEPYEYDVLLLAENGLEL 1113

  Fly   670 STSKRKFDEI------------ESSVSNYKECYVEFAVP---------NLRTDILPTIKCDQCGA 713
            .:..:..|::            |::...:...|.....|         ..|..:...|.|:.|..
Mosquito  1114 LSDNKSLDQLYLFLRYLHRLVKETASCFWHRAYCSVVRPIQEQMLTMYGRRLAVPGNIDCELCNK 1178

  Fly   714 N 714
            |
Mosquito  1179 N 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	107/502 (21%)
		zf_UBZ	705..736	CDD:465769	4/10 (40%)
		zf_UBZ	805..832	CDD:465769
Rev1	XP_061501327.1	None