DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and ESCO1

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_443143.2	Gene:	ESCO1 / 114799	HGNCID:	24645	Length:	840	Species:	Homo sapiens

Alignment Length:	678	Identity:	121/678 - (17%)
Similarity:	235/678 - (34%)	Gaps:	189/678 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 KFSEVDLQRKFDEKNGTWLFN--ISRGIDLEAVTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLG 357
            |.::.:|:.:...::.....|  .::.|:...||.|.||:            ..|..|..|..|.
Human    56 KINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQ------------ESTKKKLSQKKLV 108

  Fly   358 ELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVASSRSTALRDYD-QESIVRLSLDLIKAN 421
            ..:.:.|::|       |||::.:  |.:.::      |.||...|:.. |...|:.||...|..
Human   109 HENPKANEQL-------NRRSQRL--QQLTEV------SRRSLRSREIQGQVQAVKQSLPPTKKE 158

  Fly   422 TKTFLRPGSESALNNAIKFLGISVGKFETVSSGQNKLQEMFANQAAKKRRV-------------S 473
            ..:..:..|.......:|...:.| |.::.......:.|:..:...|||:|             .
Human   159 QCSSTQSKSNKTSQKHVKRKVLEV-KSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQ 222

  Fly   474 GDE--PGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISANPLAAAAGAPNKNFVE 536
            |.|  |.:..:.:..|....|.|.|....                        |.:..|.||
Human   223 GSEKCPQKTTRRDETKPVPVTSEVKRSKM------------------------ATSVVPKKN--- 260

  Fly   537 EYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTS---------REDSLDVQE 592
            |.|..:|..|.| .|.|..:|...........|:|..|: ::||:..         ..|:::|::
Human   261 EMKKSVHTQVNT-NTTLPKSPQPSVPEQSDNELEQAGKS-KRGSILQLCEEIAGEIESDNVEVKK 323

  Fly   593 LAEELDAIEADNSKDFE-EDTEEETELTSD--------------THMSKP-----EGQSSDAGQE 637
            .:.::::::.:...:.: |:|..|.::...              :..:||     .|.:|.|.:.
Human   324 ESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKN 388

  Fly   638 QDPNTLNDSTGNDL--------------YVETGIVPPTL-TEDELKPST-------------SKR 674
            .:...:..|..|.:              .:.|...||.| ....:..||             .:.
Human   389 SNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQE 453

  Fly   675 KFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVK------------SLQTHRD 727
            |..||.|......:..||.   |..|:..|    :.|  ::.:|:|            |..:..:
Human   454 KMKEINSEEVKINDITVEI---NKTTERAP----ENC--HLANEIKPSDPPLDNQMKHSFDSASN 509

  Fly   728 HHFAQELSRTLRSTEREERTQSRQKISLKPTPPKKSKKTAGSGSSSY-STAPPSNSITKFFRAKP 791
            .:|:|.|...|.::..|..|.:...:         |:....:|.:.: .:||..:||.....:|.
Human   510 KNFSQCLESKLENSPVENVTAASTLL---------SQAKIDTGENKFPGSAPQQHSILSNQTSKS 565

  Fly   792 TQEQAPSDPQMNQCPECKAFIKCVDMPEHLDYHVARNLQ-RELNQQDLRTRTAALNKEKISPV-- 853
            :..:  ..|:.:..|:|.:         ||:..:.::|: :|..:.|.:.......:::...|
Human   566 SDNR--ETPRNHSLPKCNS---------HLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSC 619

  Fly   854 ----------QPKKQSQKKL--NSTISA 869
                      .|:.::|..|  |..|||
Human   620 NVCGMLYTASNPEDETQHLLFHNQFISA 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	31/154 (20%)
		zf_UBZ	705..736	CDD:408236	7/42 (17%)
		zf_UBZ	805..832	CDD:408236	5/27 (19%)
ESCO1	NP_443143.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..188		32/159 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..300		22/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..338		1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..505		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..582		9/41 (22%)
		zf-C2H2_3	604..643	CDD:290589	4/38 (11%)
		Acetyltransf_13	763..825	CDD:290591
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:27112597, ECO:0000269\|PubMed:27803161, ECO:0007744\|PDB:4MXE, ECO:0007744\|PDB:5T53	772..774
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:27112597, ECO:0000269\|PubMed:27803161, ECO:0007744\|PDB:4MXE, ECO:0007744\|PDB:5T53	780..785
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:27112597, ECO:0000269\|PubMed:27803161, ECO:0007744\|PDB:4MXE, ECO:0007744\|PDB:5T53	812..814
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030