DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-eta and POLI

DIOPT Version :9

Sequence 1:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_009126.2	Gene:	POLI / 11201	HGNCID:	9182	Length:	740	Species:	Homo sapiens

Alignment Length:	865	Identity:	195/865 - (22%)
Similarity:	322/865 - (37%)	Gaps:	256/865 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQ-YNPWRGGGIIAVNYAARAKGVTRHMRGD 75
            |...||::.||:|||:.|||...:||.:::||.|.| |.      ::..||.||..||.:.|...
Human    49 NASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYL------VVTCNYEARKLGVKKLMNVR 107

  Fly    76 EAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQ 140
            :||:.||::||.      ...|.::||:...:|..:|:.|:.::||...||.::|:||.|..|:|
Human   108 DAKEKCPQLVLV------NGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQ 166

  Fly   141 QMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRL 205
            |:||       .||......|:                          .|:...:..:....|||
Human   167 QLQS-------DELSAVTVSGH--------------------------VYNNQSINLLDVLHIRL 198

  Fly   206 LIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSL-PVGK 269
            |:|:.:|.|:|.|:..:.|....||:|.||:||||.:|:.|||:||:|.......|..|| .:.:
Human   199 LVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKE 263

  Fly   270 IKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAV----TPRFY 330
            |.|:|.|..:.: |.|||..:..:..||...|:::........:..:|.|.|...|    .|:.:
Human   264 IPGIGYKTAKCL-EALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSF 327

  Fly   331 SKSIG---CCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGE 392
            |:...   |..:...:|.|.          ||.:.:.:|:.:|     .|..|.|
Human   328 SEEDSFKKCSSEVEAKNKIE----------ELLASLLNRVCQD-----GRKPHTV---------- 367

  Fly   393 EVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESAL-NNAIKFLGISVGKFETVSSGQN 456
                  ...:|.|..|              |.:.|...:..: ::.|:.||  .|.::.::...:
Human   368 ------RLIIRRYSSE--------------KHYGRESRQCPIPSHVIQKLG--TGNYDVMTPMVD 410

  Fly   457 KLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANY--LQGAKKEDAKADGIS 519
            .|.::|.|....|.      |..|..:.:              .|.|.  |..|||      |:.
Human   411 ILMKLFRNMVNVKM------PFHLTLLSV--------------CFCNLKALNTAKK------GLI 449

  Fly   520 ANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQK------KTGQQ 578
            ...|..:....:::....:|                    .|::....:.|.::      .:|:.
Human   450 DYYLMPSLSTTSRSGKHSFK--------------------MKDTHMEDFPKDKETNRDFLPSGRI 494

  Fly   579 GSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQDPNTL 643
            .|..:||..||....::|         ||..|          ....|.|||...:..::.
Human   495 ESTRTRESPLDTTNFSKE---------KDINE----------FPLCSLPEGVDQEVFKQL----- 535

  Fly   644 NDSTGNDLYVETGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKC 708
                            |...::|:....|:.|| :.:.|||
Human   536 ----------------PVDIQEEILSGKSREKF-QGKGSVS------------------------ 559

  Fly   709 DQCGANIPDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKISLKPTPPKKSKKTAG--SGS 771
              |..:....|.|.       |:::..:.:....|:..:.|:|..|:.|..|    .|:|  |.|
Human   560 --CPLHASRGVLSF-------FSKKQMQDIPINPRDHLSSSKQVSSVSPCEP----GTSGFNSSS 611

  Fly   772 SSYSTAPPSNSITKFFRAKPTQ-EQAPSDPQ----MNQCPECKAFIKCVDMPEHLDYHVARNLQR 831
            |||.::....|.....|.|..: .|.|.:||    .|..|...||            |...|||.
Human   612 SSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAF------------HSFPNLQS 664

  Fly   832 ELNQQDLRTRTAALNKEKIS 851
            |  |...|..|...:|:.::
Human   665 E--QLFSRNHTTDSHKQTVA 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	115/436 (26%)
		zf_UBZ	705..736	CDD:408236	4/30 (13%)
		zf_UBZ	805..832	CDD:408236	7/26 (27%)
POLI	NP_009126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		DinP	53..390	CDD:223466	114/427 (27%)
		PolY_Pol_iota	56..437	CDD:176457	123/493 (25%)
		DNA binding. /evidence=ECO:0000269\|PubMed:15254543, ECO:0000269\|PubMed:27555320, ECO:0007744\|PDB:1T3N, ECO:0007744\|PDB:5KT2, ECO:0007744\|PDB:5KT4, ECO:0007744\|PDB:5KT6	249..314		16/65 (25%)
		DNA binding. /evidence=ECO:0000269\|PubMed:15254543, ECO:0000269\|PubMed:27555320, ECO:0007744\|PDB:1T3N, ECO:0007744\|PDB:5KT2, ECO:0007744\|PDB:5KT4, ECO:0007744\|PDB:5KT6	325..439		28/180 (16%)
		Ubiquitin-binding 1 (UBM1). /evidence=ECO:0000250\|UniProtKB:Q6R3M4	527..544		2/37 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..615		12/37 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..704		2/12 (17%)
		Ubiquitin-binding 2 (UBM2). /evidence=ECO:0000250\|UniProtKB:Q6R3M4	708..725
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850