Protein Alignment PolH and POLI

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_009126.2
• Gene: POLI / 11201
• HGNCID: 9182
• Length: 740
• Species: Homo sapiens
• Alignment Length: 865
• Identity: 195/865 - (22%)
• Similarity: 322/865 - (37%)
• Gaps: 256/865 - (29%)

  Fly    12 NKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQ-YNPWRGGGIIAVNYAARAKGVTRHMRGD 75
            |...||::.||:|||:.|||...:||.:::||.|.| |.      ::..||.||..||.:.|...
Human    49 NASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYL------VVTCNYEARKLGVKKLMNVR 107

  Fly    76 EAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQ 140
            :||:.||::||.      ...|.::||:...:|..:|:.|:.::||...||.::|:||.|..|:|
Human   108 DAKEKCPQLVLV------NGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQ 166

  Fly   141 QMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRL 205
            |:||       .||......|:                          .|:...:..:....|||
Human   167 QLQS-------DELSAVTVSGH--------------------------VYNNQSINLLDVLHIRL 198

  Fly   206 LIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSL-PVGK 269
            |:|:.:|.|:|.|:..:.|....||:|.||:||||.:|:.|||:||:|.......|..|| .:.:
Human   199 LVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKE 263

  Fly   270 IKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAV----TPRFY 330
            |.|:|.|..:.: |.|||..:..:..||...|:::........:..:|.|.|...|    .|:.:
Human   264 IPGIGYKTAKCL-EALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSF 327

  Fly   331 SKSIG---CCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGE 392
            |:...   |..:...:|.|.          ||.:.:.:|:.:|     .|..|.|
Human   328 SEEDSFKKCSSEVEAKNKIE----------ELLASLLNRVCQD-----GRKPHTV---------- 367

  Fly   393 EVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESAL-NNAIKFLGISVGKFETVSSGQN 456
                  ...:|.|..|              |.:.|...:..: ::.|:.||  .|.::.::...:
Human   368 ------RLIIRRYSSE--------------KHYGRESRQCPIPSHVIQKLG--TGNYDVMTPMVD 410

  Fly   457 KLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANY--LQGAKKEDAKADGIS 519
            .|.::|.|....|.      |..|..:.:              .|.|.  |..|||      |:.
Human   411 ILMKLFRNMVNVKM------PFHLTLLSV--------------CFCNLKALNTAKK------GLI 449

  Fly   520 ANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQK------KTGQQ 578
            ...|..:....:::....:|                    .|::....:.|.::      .:|:.
Human   450 DYYLMPSLSTTSRSGKHSFK--------------------MKDTHMEDFPKDKETNRDFLPSGRI 494

  Fly   579 GSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQDPNTL 643
            .|..:||..||....::|         ||..|          ....|.|||...:..::.
Human   495 ESTRTRESPLDTTNFSKE---------KDINE----------FPLCSLPEGVDQEVFKQL----- 535

  Fly   644 NDSTGNDLYVETGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKC 708
                            |...::|:....|:.|| :.:.|||
Human   536 ----------------PVDIQEEILSGKSREKF-QGKGSVS------------------------ 559

  Fly   709 DQCGANIPDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKISLKPTPPKKSKKTAG--SGS 771
              |..:....|.|.       |:::..:.:....|:..:.|:|..|:.|..|    .|:|  |.|
Human   560 --CPLHASRGVLSF-------FSKKQMQDIPINPRDHLSSSKQVSSVSPCEP----GTSGFNSSS 611

  Fly   772 SSYSTAPPSNSITKFFRAKPTQ-EQAPSDPQ----MNQCPECKAFIKCVDMPEHLDYHVARNLQR 831
            |||.::....|.....|.|..: .|.|.:||    .|..|...||            |...|||.
Human   612 SSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAF------------HSFPNLQS 664

  Fly   832 ELNQQDLRTRTAALNKEKIS 851
            |  |...|..|...:|:.::
Human   665 E--QLFSRNHTTDSHKQTVA 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	115/436 (26%)
		zf_UBZ	705..736	CDD:465769	4/30 (13%)
		zf_UBZ	805..832	CDD:465769	7/26 (27%)
POLI	NP_009126.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		PolY_Pol_iota	56..437	CDD:176457	123/493 (25%)
		DNA-binding. /evidence=ECO:0000269|PubMed:15254543, ECO:0000269|PubMed:27555320, ECO:0007744|PDB:1T3N, ECO:0007744|PDB:5KT2, ECO:0007744|PDB:5KT4, ECO:0007744|PDB:5KT6	249..314		16/65 (25%)
		DNA-binding. /evidence=ECO:0000269|PubMed:15254543, ECO:0000269|PubMed:27555320, ECO:0007744|PDB:1T3N, ECO:0007744|PDB:5KT2, ECO:0007744|PDB:5KT4, ECO:0007744|PDB:5KT6	325..439		28/180 (16%)
		Ubiquitin-binding 1 (UBM1). /evidence=ECO:0000250|UniProtKB:Q6R3M4	527..544		2/37 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..615		12/37 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	671..704		2/12 (17%)
		Rev1_UBM2	<705..730	CDD:412037
		Ubiquitin-binding 2 (UBM2). /evidence=ECO:0000250|UniProtKB:Q6R3M4	708..725