DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DNApol-eta and esco1

DIOPT Version :9

Sequence 1:NP_649371.2 Gene:DNApol-eta / 40438 FlyBaseID:FBgn0037141 Length:885 Species:Drosophila melanogaster
Sequence 2:XP_005174247.1 Gene:esco1 / 100333282 ZFINID:ZDB-GENE-130530-818 Length:933 Species:Danio rerio


Alignment Length:543 Identity:108/543 - (19%)
Similarity:193/543 - (35%) Gaps:125/543 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   372 IENNRRAKHMVV-QYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESALN 435
            |:.:...||... :.:.|:|..||.::.|  |:|..|.:.|          .|.||: .|::.|:
Zfish   218 IQESSLTKHSFSGKDISDMDELEVVNTCS--LQDSVQSTDV----------AKVFLQ-DSDAFLD 269

  Fly   436 NAIKFLG--ISVGKFETVSSGQNKLQEMFANQAAKKRRVSGDEPGQLPK-------VEMEKKQKQ 491
            :.::...  :.:..:|.:...|.::.:...::....:.|:...  .||:       .|:.|||..
Zfish   270 DDVEIENCVVEIETYEDLDGDQGEVSKKQTSECVTCKEVNSSP--SLPQESATDSSQELPKKQAM 332

  Fly   492 TDEFKMKSFFANYLQGAKKEDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTST 556
            ..:.:.|              |:...::....|||...|.::|     :.|.........:.:..
Zfish   333 NPQARTK--------------ARLAALAEERAAAAKKPPPRHF-----NLLALCEEIADDIASDA 378

  Fly   557 PAEFKESFFSQYLKQQKKTGQQGSVTSRED--SLDVQELAEELDAIEADNSKDFEEDTEEETELT 619
            |.           ...|.|.:|    .:||  |.||.|..|..::.:|..||:..|        :
Zfish   379 PG-----------ASDKTTNEQ----QQEDHESEDVSECTEVSESKDASESKEVNE--------S 420

  Fly   620 SDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTEDELKP----STSKRKFDEIE 680
            .|...||...:|.|..:.::.:........::..|....|.|..|:...|    .|.|::|...:
Zfish   421 KDLSESKDASESKDVSENKEVSETETCEPEEVVSENTAPPGTPNEETADPRPEDGTPKKRFFLSQ 485

  Fly   681 SSVSNYKECYVEFAVPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQ-ELSRTLRSTERE 744
            .||.             |:|                .|.|.|.  |.....| ||.|...:..|.
Zfish   486 MSVP-------------LKT----------------QEKKKLS--RFQRLRQVELQRDKLTWTRV 519

  Fly   745 ERTQSRQKISLKPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQ---EQAPSDPQMNQCP 806
            ::.:|.|..........::...:.|.:::.:..|.:.|:.|....:|.:   .|||..|.....|
Zfish   520 KKLKSDQVNQAGSQKDSEASSVSPSPATTPAQVPTTESVPKVGSVEPKRVLPAQAPPMPNGITSP 584

  Fly   807 ECKAFIKCVDMPEHLDYHVARNLQR---ELN--QQDLRTRTAALN--KEKISP----VQPKKQSQ 860
            :.|..:      |:..|...|....   ||:  ::|.....|..|  |.:.||    |||....:
Zfish   585 KPKPVV------EYKPYTPRRKYSPDDFELDGFEEDTAKPAAPKNVGKAEQSPSSAKVQPNPAVE 643

  Fly   861 KKLNSTISASSSGTKTIAQFFSQ 883
            :||....:|.|....:..|..:|
Zfish   644 RKLCVPTTADSKSKSSPQQETAQ 666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-etaNP_649371.2 PolY_Pol_eta 20..447 CDD:176456 17/77 (22%)
zf_UBZ 705..736 CDD:408236 7/31 (23%)
zf_UBZ 805..832 CDD:408236 5/29 (17%)
esco1XP_005174247.1 zf-C2H2_3 703..737 CDD:290589
Acetyltransf_13 856..918 CDD:290591
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4551
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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