DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and SV2A

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001315603.1	Gene:	SV2A / 9900	HGNCID:	20566	Length:	742	Species:	Homo sapiens

Alignment Length:	705	Identity:	135/705 - (19%)
Similarity:	219/705 - (31%)	Gaps:	257/705 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAASEAPPADPAVEVAPPAKDSEDVT--LDAILKHLGQFGRFQLIIFLLICLPMMFHA--MFSVT 61
            ::..|.||....  .|...|:.|::.  .:|||:..|. ||||..::.::.|.:|...  :|.|.
Human   126 LSDGEGPPGGRG--EAQRRKEREELAQQYEAILRECGH-GRFQWTLYFVLGLALMADGVEVFVVG 187

  Fly    62 YVFTAATVTHRCSVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADH 126
            :|..:|                                                  ..|:|.:|
Human   188 FVLPSA--------------------------------------------------EKDMCLSD- 201

  Fly   127 FTKNKEACAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSF 191
              .||                               .|:|.|..||...|..:.|.:|||.||..
Human   202 --SNK-------------------------------GMLGLIVYLGMMVGAFLWGGLADRLGRRQ 233

  Fly   192 SIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITV 256
            .:.:...:.:|.....||...||.||....|..:.........|....|.:..::|....|.:.:
Human   234 CLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCM 298

  Fly   257 FYAVGEVLLAM----------------SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLS 305
            |:.:|.|..|.                ||..||.||:.:.:...||:..:......|||.|:.|.
Human   299 FWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLE 363

  Fly   306 QGKEERAKNILRRAAHVNKREL--PESVLD----KLVLANRDKLQQSSES-----RFPIR----- 354
            .||.:.|..:|::....|.|..  ||.|..    |.:....:.::..|::     |:.:|
Human   364 NGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLG 428

  Fly   355 -EAFKNF------KWRIANCSL--CWIVHVLVYYGLS---------------------------- 382
             :.:.||      ::|.....:  .|......||||:
Human   429 GQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVE 493

  Fly   383 ----------------------------------------------------------LNVVLLD 389
                                                                      :|.|..:
Human   494 HVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYN 558

  Fly   390 GD----KYNNF------------------------AYI--------ALVEIPGFFMPLLIMDRFG 418
            .|    |:.|.                        ||:        .|..:||..:..|:||:.|
Human   559 TDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIG 623

  Fly   419 RRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLL 483
            |...|.|..:.|.:.|....|..::..::.| |.|.|.::| ||:..|.....|:||::.|.:..
Human   624 RLRMLAGSSVMSCVSCFFLSFGNSESAMIAL-LCLFGGVSI-ASWNALDVLTVELYPSDKRTTAF 686

  Fly   484 SFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSG-LLTLFFPETTNVVL 537
            .|.:.:.:..::|.............|..:|||.||:..| .|.|..|||...||
Human   687 GFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	126/669 (19%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	105/547 (19%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	135/705 (19%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..144		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910