DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and SLC22A13

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	553	Identity:	157/553 - (28%)
Similarity:	265/553 - (47%)	Gaps:	50/553 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT-NWS 93
            :|..:|.|||||:.:.:|:|:.......:...:||......|.|:|.        :.:.|| |.|
Human     7 VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVA--------WVKNHTFNLS 63

  Fly    94 IPKN---GKDLDS------CNRYTNSELPQWNHSV-DICSADHFTKNKEACAHNEFVFRDDEV-T 147
            ..:.   ...||:      |..:   ..|..|.|: ||.|  |.....:.|... :.:.::.: :
Human    64 AAEQLVLSVPLDTAGHPEPCLMF---RPPPANASLQDILS--HRFNETQPCDMG-WEYPENRLPS 122

  Fly   148 ISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPS 212
            :.|:|.:.||.:.......::...|...|..:.|.:.||.||..:|....:|..::|:..:|.||
Human   123 LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPS 187

  Fly   213 YGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRI 277
            :..::...|......:.|..:...:..|.|||..|..|..:....:::|:::||..|..|.:||:
Human   188 FELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRL 252

  Fly   278 LLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDK 342
            |......|.|:|..|||.||||.||||::|:.:.|..::::||.||:|:|...::::||
Human   253 LQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLV------ 311

  Fly   343 LQQSSESRFPIREAFKNFKW----RIANCSLC-WIVHVLVYYGLSLNVVLLDGDKYNNFAYIALV 402
                .|...|...|...|:.    ::.....| |.|..|.||||||.|.....|.|........|
Human   312 ----PEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAV 372

  Fly   403 EIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLY 467
            |:|.....:.:|.||||::|..|.::..||.||..||..||.||:..:|.:|||:...|:|.:.|
Human   373 EVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISY 437

  Fly   468 FFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPET 532
            .:::|::||.||.:.:....:..|.|.:|.|...||.:|:|..|.:::....||:|||....|||
Human   438 VYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPET 502

  Fly   533 TNVVLPTTVQEAD---------AIGVKKQSKSK 556
            ....|..|:|:.:         ::..:|::::|
Human   503 HGQGLKDTLQDLELGPHPRSPKSVPSEKETEAK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	152/521 (29%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	120/389 (31%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	152/521 (29%)
		MFS	139..500	CDD:119392	116/370 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030