Protein Alignment SLC22A and SLC22A8

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001171661.1
• Gene: SLC22A8 / 9376
• HGNCID: 10972
• Length: 542
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 148/560 - (26%)
• Similarity: 257/560 - (45%)
• Gaps: 61/560 - (10%)

  Fly    25 VTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPH 89
            :|...||..:|..|.||.:...::.||::..|..::..:|||||..|.|.            .||
Human     1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR------------PPH 53

  Fly    90 T----NWSIP--KNGKDLDSCNRYT---NSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDE 145
            .    .|.:|  .|||. :.|.|:.   |:.||           :...:..|.|. :.:|:...:
Human    54 NASTGPWVLPMGPNGKP-ERCLRFVHPPNASLP-----------NDTQRAMEPCL-DGWVYNSTK 105

  Fly   146 VTISNDFGIFCDDEWKLSMVGTINNLGQFF-GIPIGGFV----ADRYGRSFSIALGGILGAVLGV 205
            .:|..::.:.|:......|..:|     |. ||.|||.|    :||:||...:....:|.|..|.
Human   106 DSIVTEWDLVCNSNKLKEMAQSI-----FMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGS 165

  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAK 270
            ..:|||::..::||.||.....|.:..:..::.:|.|..:.|.:..:.:...|..|:.:|...|.
Human   166 GAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAY 230

  Fly   271 AFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-KRELPESV-LD 333
            |...||.|......|..:.....|..|||:|||:..||..:|..||||.|..| |:|..|.: |:
Human   231 AIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLE 295

  Fly   334 KLVLANRDKLQQSSESRFPIREAFK-NFKWRIANC-SLCWIVHVLVYYGLSLNVVLLDGDKYNNF 396
            :|.| |..|....:::::...:.|: ....|:..| ||.|......||.|::.|     :::...
Human   296 ELKL-NLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGV-----EEFGVN 354

  Fly   397 AYIAL-----VEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGK 456
            .||..     |::|..|:.:|.:...||..:....:|.:|...:...|...|...::.||.:.||
Human   355 LYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGK 419

  Fly   457 LTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIV 521
            ..:::||..|:.:.||:|||.:|.:.:...::..|.|||::|...:..:.....|.:::...|::
Human   420 GCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALL 484

  Fly   522 SGLLTLFFPETTNVVLPTTVQEAD--AIGVKKQSKSKDLD 559
            .|...||.|||.|..||.|:::.:  ::..||..:..:::
Human   485 GGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVE 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	142/527 (27%)
		MFS	146..530	CDD:119392	107/397 (27%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	142/527 (27%)
		MFS	96..493	CDD:119392	108/408 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..542		2/10 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030