DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a7

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	156/554 - (28%)
Similarity:	252/554 - (45%)	Gaps:	49/554 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN-W- 92
            :|..:|.||.|||...:|:.||.|...|..:..||.||...|.|:     |||:.....|.: |
  Rat     6 LLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCA-----LPGAPANLSHQDLWL 65

  Fly    93 --SIPK-NGKDLDSCNRY---------------TNSELPQWNHSVDICSADHFTKNKEACAHNEF 139
              .:|: ......||.|:               :||..|:.......||...           |:
  Rat    66 EAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPLTVPCSQGW-----------EY 119

  Fly   140 VFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLG 204
            ...:...||:.::.:.|.......:..|...:|...|..:.|:::||:||...:.:..:...|||
  Rat   120 DRSEFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLG 184

  Fly   205 VIRSFSPSYGWFLVFEFLDNMTSSTLYS-TCFVIGIEL--VGPKRRVLACSVITVFYAVGEVLLA 266
            ::.:.|.:|..|:|..   .:|.|.|.. |..|:.:||  :..:.|.:|..:.|||::.|.:|||
  Rat   185 LMSAASINYIMFVVTR---TLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGVLLLA 246

  Fly   267 MSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESV 331
            :.......||.||.....|.:..:...|.:|||.||||:||:.|.||..|...|.:|.|.:.|..
  Rat   247 LVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGS 311

  Fly   332 LDKLVLANRDKLQQSSESRFPIREAFKNFKWRIAN--CSLCWIVHVLVYYGLSLNVVLLDGDKYN 394
            |.:..|.|...::::.: |....:.|:..:.|..:  |.:.|......||||:|:|..|..:.|.
  Rat   312 LSQEALNNVVTMERALQ-RPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQ 375

  Fly   395 NFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTI 459
            .......||:|...|...::.|.|||.:..|::|.:.|....::....:.......|.:|||...
  Rat   376 TQLLFGAVELPSKIMVYFLVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITALVVVGKAFS 440

  Fly   460 TASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGL 524
            .|:|...|.|.||:|||.||.:.|...::|||.|:.|||...||...:...|.:.:.|.|:|:..
  Rat   441 EAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAAC 505

  Fly   525 LTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDL 558
            ..|..|||....||.|:|:.:    :|.::.:|:
  Rat   506 TALLLPETKKAQLPETIQDVE----RKSTQEEDV 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	151/529 (29%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	114/388 (29%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	151/529 (29%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	111/370 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020