DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and PHO84

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_013583.1	Gene:	PHO84 / 854916	SGDID:	S000004592	Length:	587	Species:	Saccharomyces cerevisiae

Alignment Length:	486	Identity:	104/486 - (21%)
Similarity:	188/486 - (38%)	Gaps:	113/486 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 VGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIR---SFSPSYGWFLVFEF----- 221
            |||:  :|| ||.   |.:||..||.....:..|:..|..:::   :.||:..:..|..|
Yeast   113 VGTV--IGQ-FGF---GTLADIVGRKRIYGMELIIMIVCTILQTTVAHSPAINFVAVLTFYRIVM 171

  Fly   222 ---------LDNMTSSTLYSTCF---VIGIELVGPKRRVLACSVITVFYAV---GEVLLAMSA-- 269
                     |.::.:|...:|.:   ::|..........::..:|.:....   ||:..|.|.
Yeast   172 GIGIGGDYPLSSIITSEFATTKWRGAIMGAVFANQAWGQISGGIIALILVAAYKGELEYANSGAE 236

  Fly   270 ------KAFHD-WRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHV--NKR 325
                  ||... ||||:.:.....|..|.:...:|||.|:.|    :..||..|..||..  .::
Yeast   237 CDARCQKACDQMWRILIGLGTVLGLACLYFRLTIPESPRYQL----DVNAKLELAAAAQEQDGEK 297

  Fly   326 ELPESVLDKLVLANRDKLQQSSES--RFPIREAFKNF-----KWRIANCSL----CWIVHVLVYY 379
            ::.::..:.:.:...::...:.||  ..|.:.:||:|     :|:.....|    .|....:.:|
Yeast   298 KIHDTSDEDMAINGLERASTAVESLDNHPPKASFKDFCRHFGQWKYGKILLGTAGSWFTLDVAFY 362

  Fly   380 GLSLN-VVLLD-----GDK----------YNNFAYIALVEIPGFFMPLLIMDRFGRR-YSLCGLM 427
            ||||| .|:|.     |.|          ..|...|....:||:::.:..:|..||: ..|.|.:
Yeast   363 GLSLNSAVILQTIGYAGSKNVYKKLYDTAVGNLILICAGSLPGYWVSVFTVDIIGRKPIQLAGFI 427

  Fly   428 LASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFAS------------EIYPTNLRN 480
            :.:.|.|           |:......:|...:.|.:.:..||.:            |.:||..|:
Yeast   428 ILTALFC-----------VIGFAYHKLGDHGLLALYVICQFFQNFGPNTTTFIVPGECFPTRYRS 481

  Fly   481 SLLSFCSMMGRFGSMLAPQTPLLAKYYANA-----------PAM--LFAGAAIVSGLLTLFFPET 532
            :.....:..|:.|:::| ||.|......|.           |.:  :||...::....||..|||
Yeast   482 TAHGISAASGKVGAIIA-QTALGTLIDHNCARDGKPTNCWLPHVMEIFALFMLLGIFTTLLIPET 545

  Fly   533 TNVVLPTTVQ----EADAIGVKKQSKSKDLD 559
            ....|....:    |.|...:..::|:.|::
Yeast   546 KRKTLEEINELYHDEIDPATLNFRNKNNDIE 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	100/461 (22%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	96/451 (21%)
PHO84	NP_013583.1	2A0109	49..554	CDD:129965	100/462 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000