Protein Alignment SLC22A and SLC22A16

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 157/572 - (27%)
• Similarity: 255/572 - (44%)
• Gaps: 66/572 - (11%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSN----YYEP 88
            :.|..|:|.|||||.:::.:.....:...:..:..||...|..|.|.      |..|    .:..
Human     7 EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCR------PPGNVSQVVFHN 65

  Fly    89 HTNWSIPKNGKDLDSCNR-YTNSELPQ---WNHSVDICSAD----------HFTKNKE--ACA-- 135
            |:|||:...|..|.|..: |...:|..   |  .:..||.:          .:|.:|:  .|.
Human    66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIW--ELSRCSRNKRENTSSLGYEYTGSKKEFPCVDG 128

  Fly   136 --HNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGR-------SF 191
              :::..::...||   .:.:.||.:|...::..:...|...|....|:.:||.||       |.
Human   129 YIYDQNTWKSTAVT---QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSS 190

  Fly   192 SIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITV 256
            |:.|.||..|       |:..|..|:...|...|.:|......||..:|.:|.|.|..|...:..
Human   191 SMFLFGIAAA-------FAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHS 248

  Fly   257 FYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNIL----- 316
            |:|||.:|:|::......|.:...|....::..:...|:|||:..||||:|:.|.|:.|:
Human   249 FFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAK 313

  Fly   317 -RRAAHVNKRELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCS----LCWIVHVL 376
             .||:.....||....|...|..:..::|:.:.|       :..:.|.|...:    |.|....|
Human   314 WNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLS-------YLFYNWSITKRTLTVWLIWFTGSL 371

  Fly   377 VYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTG 441
            .:|..|||.|.|.|::|.|...:.:||||.:....:.||:.|||..|...:..|.|.|...:...
Human   372 GFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIP 436

  Fly   442 ADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKY 506
            ....:|.:|..:|||..|.|:|.::|.:.:|:|||.:|:..:...||:.|..|:|||.:..|:..
Human   437 QKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSI 501

  Fly   507 YANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDL 558
            :...|.:.....|::||:|||..|||....|.||.:||..:..:.:|||..|
Human   502 WIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKL 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	147/545 (27%)
		MFS	146..530	CDD:119392	115/400 (29%)
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	147/545 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		4/11 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930