DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and HXT9

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_012316.1	Gene:	HXT9 / 853236	SGDID:	S000003755	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	109/522 - (20%)
Similarity:	195/522 - (37%)	Gaps:	118/522 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEAC---AHNEFVFRDDEVTIS-------- 149
            ||..:||:..  ...:|||...|.       :|.....|   |...|:|..|..|||
Yeast    36 KNSLNLDATE--PPIDLPQKPLSA-------YTTVAILCLMIAFGGFIFGWDTGTISGFVNLSDF 91

  Fly   150 -------NDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGA---VLG 204
                   ||.|.:...:.::.::.:|.|:    |..|||.|..:.|..:...:|.|...   |:|
Yeast    92 IRRFGQKNDKGTYYLSKVRMGLIVSIFNI----GCAIGGIVLSKVGDIYGRRIGLITVTAIYVVG 152

  Fly   205 VIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIG---IELVGPKR--------RVLACSV-ITVF 257
            ::...:....|:..  |:..:.|........|:.   |..|.||:        ..|.|:: |.:.
Yeast   153 ILIQITSINKWYQY--FIGRIISGLGVGGIAVLSPMLISEVAPKQIRGTLVQLYQLMCTMGIFLG 215

  Fly   258 YAVGEVLLAMSAKAFHD---WRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRA 319
            |...     ...|.:|:   ||:.|.:.:..:..:::....:|||.|:|:..||:|.||..|.::
Yeast   216 YCTN-----YGTKNYHNATQWRVGLGLCFAWTTFMVSGMMFVPESPRYLIEVGKDEEAKRSLSKS 275

  Fly   320 AHVNKRELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKW--------RIANCSLCWIV--- 373
            ..|       ||.|..:||..|.::...|    :.:...|..|        ::....|..::
Yeast   276 NKV-------SVDDPALLAEYDTIKAGIE----LEKLAGNASWSELLSTKTKVFQRVLMGVMIQS 329

  Fly   374 -------HVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASG 431
                   :...|||.::...:...|.:.....|.:|.....|:.:..::|||||  .|.|..|:.
Yeast   330 LQQLTGDNYFFYYGTTIFKSVGLKDSFQTSIIIGVVNFFSSFIAVYTIERFGRR--TCLLWGAAS 392

  Fly   432 LCCIGTIFT--------------------GADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPT 476
            :.|...:|.                    ||...::...:|.:.....|.: ...|...||.:|.
Yeast   393 MLCCFAVFASVGVTKLWPQGSSHQDITSQGAGNCMIVFTMFFIFSFATTWA-GGCYVIVSETFPL 456

  Fly   477 NLRNSLLSFCSMMG-RFGSMLAPQTPLLAK----YYANAPAMLFAGAAIVSGLLTLFF-PETTNV 535
            .:::..::..:... .:|.:::..||.:..    ||    ..:|.|..:.:.....|| |||..:
Yeast   457 RVKSRGMAIATAANWMWGFLISFFTPFITGAINFYY----GYVFLGCLVFAYFYVFFFVPETKGL 517

  Fly   536 VL 537
            .|
Yeast   518 TL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	109/522 (21%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	91/460 (20%)
HXT9	NP_012316.1	Sugar_tr	64..526	CDD:395036	100/485 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000