Protein Alignment SLC22A and TPO2

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_011654.1
• Gene: TPO2 / 853039
• SGDID: S000003370
• Length: 614
• Species: Saccharomyces cerevisiae
• Alignment Length: 406
• Identity: 81/406 - (19%)
• Similarity: 146/406 - (35%)
• Gaps: 102/406 - (25%)

  Fly    76 EECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSV-----DICSADHFTKNKEACA 135
            |..|..|.|..:|...:.....|   |..|.:......:|:::|     .||.|     ...||
Yeast   134 EREDQSGENELDPEIEFVTFVTG---DPENPHNWPSWVRWSYTVLLSILVICVA-----YGSAC- 189

  Fly   136 HNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINN-----LGQFFGIPIGGFVADRYGR--SFSI 193
                        ||...|. .:.::.:.|...|.:     :|...|..|...|:|.|||  ::.:
Yeast   190 ------------ISGGLGT-VEKKYHVGMEAAILSCSLMVIGFSLGPLIWSPVSDLYGRRVAYFV 241

  Fly   194 ALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIG--IELVGPKRRVLACSVITV 256
            ::|  |..:..:..:.:|:.|..|...||..:.||:  ..|.|.|  .::...:.|..|.:....
Yeast   242 SMG--LYVIFNIPCALAPNLGCLLACRFLCGVWSSS--GLCLVGGSIADMFPSETRGKAIAFFAF 302

  Fly   257 FYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWI--LPESVRWLLSQGKEERAKNIL--R 317
            ...||.|:..: ...|      :.::.|...::   ||:  ....|.|::|....|....::  |
Yeast   303 APYVGPVVGPL-VNGF------ISVSTGRMDLI---FWVNMAFAGVMWIISSAIPETYAPVILKR 357

  Fly   318 RAAHVNKRELPESVLDKLVLANRDKLQQSSESR---------FPIREAFKNFKWRIANCSLCWIV 373
            :||.:.|    |:...|::.....:....||..         |.:.|..     .:|.|....::
Yeast   358 KAARLRK----ETGNPKIMTEQEAQGVSMSEMMRACLLRPLYFAVTEPV-----LVATCFYVCLI 413

  Fly   374 HVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLM----LASGLCC 434
            :.|:|                  |:.       |..|::..:.:|.:.:|.|||    :...|..
Yeast   414 YSLLY------------------AFF-------FAFPVIFGELYGYKDNLVGLMFIPIVIGALWA 453

  Fly   435 IGTIFTGADQPVLQLV 450
            :.|.|. .:...||:|
Yeast   454 LATTFY-CENKYLQIV 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	66/341 (19%)
TPO2	NP_011654.1	MFS_Tpo1_MDR_like	173..599	CDD:340881	72/364 (20%)