DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and OCT2

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_178054.1	Gene:	OCT2 / 844274	AraportID:	AT1G79360	Length:	527	Species:	Arabidopsis thaliana

Alignment Length:	592	Identity:	144/592 - (24%)
Similarity:	241/592 - (40%)	Gaps:	118/592 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ADPAVEVAPPAKDSEDVTL-DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHR 72
            |:|...:...:..|...:| |.|..::|.||..|.:...|:....:|.|..:...|||.:..|..
plant     2 AEPTQPLLTDSNSSSPRSLDDTIESYIGSFGWAQFLQAALVSFSGVFDAQQTFISVFTDSEPTWH 66

  Fly    73 C--SVEECDLPGSNY-YEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEAC 134
            |  |...|....||. ..|.|.||                     |::|
plant    67 CTDSNSICHESISNICILPKTAWS---------------------WDYS---------------- 94

  Fly   135 AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFV----AD-RYGRSFSIA 194
                     ..|::.:::|:.|..    |.|..:.....|.|..|||.|    || ..||...:.
plant    95 ---------PHVSVISEWGLQCAG----SFVKGLPESSFFVGCLIGGLVLSTLADSSLGRKNMLF 146

  Fly   195 LGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVF-Y 258
            |..::.|:..::..|||:...:.|..|::....:|:.:...|:..||||.|.|. ...:::.| :
plant   147 LSCLVMAISTMLTVFSPNIWVYAVLRFVNGFGRATIGTCALVLSTELVGKKWRG-RVGIMSFFGF 210

  Fly   259 AVGEVLLAMSA--KAFHDWRILLRITYGPSLI--LLAYFWILPESVRWLLSQGKEERAKNILRRA 319
            .:|.:.|.:.|  .....||||...|..|::|  :|..|::. ||.|||..:|:.|.|.:||:|.
plant   211 MLGFLSLPLMAYMNRGSSWRILYAWTSIPTIIYCVLVRFFVC-ESPRWLFVRGRREEAISILKRV 274

  Fly   320 AHVNKRELPES-----VLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCSLCWIVHV---L 376
            |.:...::...     ....|.....::...::.:.|...:.....:|.:...|....:..   |
plant   275 ASIPSTDVSSGGAISMSFSSLPFEEDEEKPSTNVNIFTTMKVLVEKRWALKRLSAVMAIAFGIGL 339

  Fly   377 VYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFT- 440
            ||||:.|.:..||.:.|.:.|:.||:::|...:.|.::|:..||.:|.|.....|:..: .||.
plant   340 VYYGMPLALSNLDFNIYLSAAFNALMDLPANLITLFLVDKLSRRNALIGFTALGGVSSV-LIFAL 403

  Fly   441 --------GADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLA 497
                    ||    |||.|.|:...:..::|.:...:..|::||.:|||.::           :|
plant   404 HNMRIGNHGA----LQLALELISYFSACSAFNMEMIYTIELFPTCVRNSAIA-----------MA 453

  Fly   498 PQTPLLAKYYANAPAMLFAGA----------AIVSGLLTLF---FPETTNVVLPTTVQEADAIGV 549
            .|..:|...:  :|.|:.||.          .:..|||.||   .|||....|..|:.|.:.
plant   454 RQALVLGGVF--SPIMVAAGRKNAFWSFGLFGLAIGLLGLFAVGLPETRGSDLCDTMDEEEC--- 513

  Fly   550 KKQSKSK 556
             |..:||
plant   514 -KDRRSK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	133/547 (24%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	107/423 (25%)
OCT2	NP_178054.1	MFS_OCT_plant	79..497	CDD:340936	115/487 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D762280at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030