DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and OCT6

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_173087.1	Gene:	OCT6 / 838207	AraportID:	AT1G16370	Length:	521	Species:	Arabidopsis thaliana

Alignment Length:	586	Identity:	134/586 - (22%)
Similarity:	232/586 - (39%)	Gaps:	127/586 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ADPAVE--VAPPAKDS--------EDVTLDAILKH-LGQFGRFQLIIFLLICLPMMFHAMFSVTY 62
            |||..|  ::....||        |.:|.|.|::. |..||.:|.....|:.|.::|.|......
plant     2 ADPISEPLLSHLTDDSGVNEKTRLEALTFDKIVEQSLSDFGFWQFFQISLVGLALLFDAQQIFIT 66

  Fly    63 VFTAATVTHRC---------SVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHS 118
            |:|.|..|..|         :.:.|.||.|.:     .|.....||
plant    67 VYTDAYPTWHCLNHTICDPSASDICKLPRSAW-----EWDGGSQGK------------------- 107

  Fly   119 VDICSADHFTKNKEACAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFV 183
                                        ::.::||:.|..    |::..:.:...:.|..:|||.
plant   108 ----------------------------SVISEFGLECSS----SLLRGMPSSAFYIGAIVGGFF 140

  Fly   184 A-----DRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVG 243
            .     |..||...:.......::..:...||.:...:...:|:...:.|..:|...|:..|.|.
plant   141 LALIPDDSLGRKKLVLFSTFAMSITSISVIFSTNVWIYTFLKFIIGFSRSQTWSYALVLISERVS 205

  Fly   244 PKRRVLACSVITVFYAVGEVLLAMSAKAF----HDWRILLRITYGPSLILLAYFWILP-ESVRWL 303
            .:.|..|..:....:.:|  .:::|..||    ..||.|...|..|::....:.::.. ||.|||
plant   206 TRWRPRATMIPFTLFVLG--FMSLSGIAFLAQDSSWRYLYLYTSVPAVFYCIFLYLFALESPRWL 268

  Fly   304 LSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCS 368
            ..|||::.|.::|.:.:...|..| |||:.||.| .::..:|:  ..:.|::.|.. ||......
plant   269 HMQGKDKEAIDVLTKMSPKEKAYL-ESVVSKLPL-KQENFEQA--PTYSIKDFFFR-KWAFRRIL 328

  Fly   369 LCWIVHV---LVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLAS 430
            :..|:..   :.|||:.|....:|.:.|.:....||||:|.|.:..::::||.||.|:
plant   329 VVMIIMFGLGISYYGVPLAARDIDVNIYLSETLNALVELPTFVITPILLERFNRRSSV------- 386

  Fly   431 GLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFAS------------EIYPTNLRNSLL 483
               .:.|:..|| ..||..||.::||..|..:|::..||.:            |::||.:|:|
plant   387 ---LVNTLLGGA-SGVLCFVLSILGKTEIAFAFELGTFFCARIGFNLMAVFMVEMFPTCVRSS-- 445

  Fly   484 SFCSMMGR----FGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEA 544
              .:||.|    .|....|....:.:|..:....:|..|....|:..|..|||..:.|..:::|.
plant   446 --ATMMFRQALVVGGACCPLIASIGRYIPSVSFAIFGIAMSGLGMFVLILPETKGLSLCDSMEEQ 508

  Fly   545 D 545
            :
plant   509 E 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	122/542 (23%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	99/412 (24%)
OCT6	NP_173087.1	MFS_OCT_plant	88..494	CDD:340936	106/483 (22%)
OCT6	NP_173087.1	xylE	<220..>314	CDD:182225	28/99 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020