DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and OCT4

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_188702.2	Gene:	OCT4 / 821613	AraportID:	AT3G20660	Length:	526	Species:	Arabidopsis thaliana

Alignment Length:	555	Identity:	144/555 - (25%)
Similarity:	261/555 - (47%)	Gaps:	73/555 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PAVEVAPPAKDSED---VTLDAIL-KHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTH 71
            |.:|..|..|::|.   :.:|.:| ::.|:|||:||..|:|.|:.....|..::..:|.......
plant    15 PLLEKIPVKKEAEGEERLCIDEMLQRYCGEFGRWQLKHFVLTCIAWALEAFHTMVMIFADQEPEW 79

  Fly    72 RCSVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAH 136
            ||...:|.:...|.....::|                     :|            |..|.:.
plant    80 RCVGSDCRVGSLNCELDPSSW---------------------EW------------TAGKGSS-- 109

  Fly   137 NEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVAD-RYGRSFSIALGGILG 200
                      |:| ::|:.|.|::|:.:|..:...|...|..:.|.::| :.||..|:.:..|:.
plant   110 ----------TVS-EWGLICGDKYKVGLVQALFFAGCMIGAGVFGHLSDSKLGRKGSLTVVCIIN 163

  Fly   201 AVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLL 265
            |:.|:..:|||:|..::|..||...::..:..|.||:..|.:||.:|.:|......|::.|..:|
plant   164 AIFGIATAFSPNYWTYVVLRFLTGFSTGGVGLTAFVLATEPIGPSKRGVAGMSTFYFFSAGIAVL 228

  Fly   266 AMSAKAFHDWRILLRITYGPSLI-LLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPE 329
            :..|..|..||.|..::..|||: ||.....:.||.||.|.:||.:.|..::...|..|.|.:|.
plant   229 SGIAYVFRSWRELFIVSSLPSLLFLLIVIPFISESPRWYLVRGKVDEAMKLMHSIAKTNGRHIPA 293

  Fly   330 SVLDKLVLANRDKLQQSS-ESRFPIREAFKN------FKWR-IANCSLCWIVHVLVYYGLSLNVV 386
            .|    .||..|.::.:: |....:..:.|:      .:.| :.:.::.:.|.: |||||||||.
plant   294 GV----TLALDDDVENNNGERNTAVEGSLKDVILSPLMRMRLVISVAISFTVSI-VYYGLSLNVG 353

  Fly   387 LLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGL-CCIGTIFTGADQ-PVLQL 449
            .|..:.|.|....|:.|:|.|.:..:::|::||:....|....|.: |.:|....||.. ..:::
plant   354 NLKTNLYLNVFVNAVSEMPAFAITAVLLDKYGRKPLSIGTQWFSCVFCLVGFSVWGAGPWKSVRM 418

  Fly   450 VLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAML 514
            |..::|...:..::.:|:.:.:|::||.:||:.|...:...:.|::|||...:|.:   ..|..:
plant   419 VSGVLGIFGMAGTYNLLFIYIAELFPTVVRNAALGCATQAAQMGAILAPFVVVLGE---ELPFGV 480

  Fly   515 FAGAAIVSGLLTLFFPETTNVVLPTT---VQEADA 546
            ||...:|.|.|..:.|||.|..|..|   :.||::
plant   481 FAVCGLVGGGLAFYLPETLNKPLYDTMFGMHEAES 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	134/516 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	110/395 (28%)
OCT4	NP_188702.2	MFS_OCT_plant	90..496	CDD:340936	115/459 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010