DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and oct2

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001107932.1	Gene:	oct2 / 797890	ZFINID:	ZDB-GENE-080204-92	Length:	554	Species:	Danio rerio

Alignment Length:	547	Identity:	156/547 - (28%)
Similarity:	255/547 - (46%)	Gaps:	35/547 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSV----EECDLPGSNYYEP 88
            |.:|:|.|.||.:|..|.:|..||::..|...:..||...|..|.|..    |:|...    .|.
Zfish     5 DELLQHAGDFGFYQKRISVLGSLPILLLAFVLIGVVFLGYTPDHWCKTASLQEKCGFS----EEQ 65

  Fly    89 HTNWSIPKNGK--DLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNE-FVFRDDEVTISN 150
            ..:.::|:.|.  ....|.::.::   ..|.|...|:...|..:....|.|| :.|.::..||..
Zfish    66 VRDLTVPRTGARGAFSKCVKFDDA---LRNGSALSCNISIFNNSTHLSACNEGWTFNENRTTIVT 127

  Fly   151 DFGIFCDDEW-----KLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILG-AVLGVIRSF 209
            :|.:.|:|.|     ::|:.|     |.|.|..:.|::|||:||. |..:..|.| .|.|....|
Zfish   128 EFSLVCEDSWLADLNQVSLAG-----GFFIGALVTGYLADRFGRK-SCFIASIFGLGVSGTCIIF 186

  Fly   210 SPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHD 274
            ||.|...|.|..|....:...::..:|:.||..|...|.....:...||::|.|||...|.....
Zfish   187 SPYYPLLLFFRCLQGFFAKGAWTATYVLIIEFFGSNNRKFVSVMSRTFYSLGLVLLPALAYYIPS 251

  Fly   275 WRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLD-KLVLA 338
            ||.|......|:.|.|.|.|::|||.||||||.|.:.|.:|::..|..|||.|||...: .|::.
Zfish   252 WRNLQLAMTLPTFIFLIYHWVIPESPRWLLSQRKTKEALSIVKSIAKCNKRSLPEDFHEMDLLIE 316

  Fly   339 NRDKLQQSSESRFPIREAFKNFKWRIANCSL--CWIVHVLVYYGLSLNVVLLDGDKYNNFAYIAL 401
            .::::.:.|     .::.||..|.|.....|  .|....:|:.||.|.:.:...:.:.:|...|:
Zfish   317 KQEEIMRPS-----YKDLFKTPKMRKHTFILIYAWFTGAVVFQGLVLRLGITGDNVFLDFLISAV 376

  Fly   402 VEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVL 466
            ||:|...:...::||.|||..:..:....|..|:...|...:...|:..:.:||:|.:....:.:
Zfish   377 VELPTGLIFYFLVDRIGRRPLMATVNFIGGAACLAVPFISPNISWLRRTIAIVGRLAVAIGNETV 441

  Fly   467 YFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPL-LAKYYANAPAMLFAGAAIVSGLLTLFFP 530
            .|..:|:|||.|||..:|.||.....|:::||.... ||..:...|.:::...:::...|.:..|
Zfish   442 NFANTELYPTPLRNLGVSVCSSASDIGAVVAPFILYRLASIWQELPLLVYGVMSVLYSGLVMLLP 506

  Fly   531 ETTNVVLPTTVQEADAIGVKKQSKSKD 557
            |...|.||.||.:.:.:..:.:.|.||
Zfish   507 EMKGVDLPETVDDVENLRSRHKRKEKD 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	148/521 (28%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	115/393 (29%)
oct2	NP_001107932.1	2A0119	12..516	CDD:273328	148/521 (28%)
oct2	NP_001107932.1	MFS	123..506	CDD:119392	115/393 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030