Protein Alignment SLC22A and Sv2c

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_083486.1
• Gene: Sv2c / 75209
• MGIID: 1922459
• Length: 727
• Species: Mus musculus
• Alignment Length: 647
• Identity: 128/647 - (19%)
• Similarity: 212/647 - (32%)
• Gaps: 243/647 - (37%)

  Fly    96 KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEF------------------VF- 141
            |:.::|:|..|....||.| .:.:.|          :.|.|..|                  ||
Mouse   118 KDRRELESERRADEEELAQ-QYELII----------QECGHGRFQWALFFVLGMALMADGVEVFV 171

  Fly   142 -------RDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL 199
                   .:.::.|.|.     ...|    :|:|..||...|....|.:||:.||..|:.:...:
Mouse   172 VGFVLPSAETDLCIPNS-----GSGW----LGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSV 227

  Fly   200 GAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVL 264
            ......:.||...||:|||...|..........|.|....|::..::|....|.:.:|:.:|.:.
Mouse   228 NGFFAFLSSFVQGYGFFLVCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIY 292

  Fly   265 LAM----------------SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAK 313
            .:.                ||..||.||:.:.:...|.:..:.....:|||.|:||..||.:.|.
Mouse   293 ASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 357

  Fly   314 NILR--------------RAAHVNKRELPESVLDKLVLANRDK--------LQQSSE-------- 348
            .||:              :...|||.:.|:.: |:|:....|.        ::..:|
Mouse   358 MILKLIHDTNMRARGQPEKVFTVNKIKTPKQI-DELIEIESDTGTWYRRCFVRIRTELYGIWLTF 421

  Fly   349 ---SRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSL---NVVL-------------LDGDKYN 394
               ..:|:||       .....::.|......|||||:   :|:.             :..|||.
Mouse   422 MRCFNYPVRE-------NTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYA 479

  Fly   395 NFA-------------------------------------------------------------- 397
            ||:
Mouse   480 NFSINFTMENQIHTGMEYENGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFDN 544

  Fly   398 --------------------------------YIA-----------LVEIPGFFMPLLIMDRFGR 419
                                            |.|           |..:||..:..|:|||.||
Mouse   545 TDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGR 609

  Fly   420 RYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLR----- 479
            ...|.|.|:.||:.|. .::.|..:.::..:|.|...|||:| :..|.....|:|||:.|
Mouse   610 LTMLGGSMVLSGISCF-FLWFGTSESMMIGMLCLYNGLTISA-WNSLDVVTVELYPTDRRATGFG 672

  Fly   480 --NSLLSFCSMMGR--FGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVL 537
              |:|....:::|.  |||:::....:        |.:|.:...:..||:.|..|:|...||
Mouse   673 FLNALCKAAAVLGNLIFGSLVSITKAI--------PILLASTVLVCGGLVGLRLPDTRTQVL 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	128/647 (20%)
		MFS	146..530	CDD:119392	111/562 (20%)
Sv2c	NP_083486.1	synapt_SV2	1..727	CDD:130366	128/647 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..128		3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910