Protein Alignment SLC22A and slc22a15.2

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001039179.1
• Gene: slc22a15.2 / 734018
• XenbaseID: XB-GENE-5824718
• Length: 487
• Species: Xenopus tropicalis
• Alignment Length: 541
• Identity: 147/541 - (27%)
• Similarity: 237/541 - (43%)
• Gaps: 69/541 - (12%)

  Fly    27 LDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN 91
            ||....::|:||..|..:...:.|..::.|..|:..|...|...:  .::..|:..|.  |.:|
 Frog     3 LDEAFLYIGEFGCCQKRLTAFLTLLQVYVACQSMLIVLVGAVPEY--LIDNEDISASK--EEYT- 62

  Fly    92 WSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISNDFGIFC 156
                   |.|...|.:| |.:.:|          |..||
 Frog    63 -------KHLHDTNNFT-SIVSEW----------HLIKN-------------------------- 83

  Fly   157 DDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEF 221
             :.:|:::..::...|...|..:.|.::|:.||......|.......|...:.:|||..|.|..|
 Frog    84 -EAYKVNLASSLFFAGLLIGNILFGPLSDKLGRRPVYLSGLFFDITFGYCTALAPSYEVFAVSRF 147

  Fly   222 LDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRITYGPS 286
            ...:.:..:....||:..|.||.....|..|:..:.:|||....|:......:||.|..:...|.
 Frog   148 FVGIMNGGMALVSFVLTQEYVGKSYWALTGSLTNLIFAVGIAFYALLGFYIRNWRTLAFVANSPG 212

  Fly   287 LILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQSSESRF 351
            :......::||||.|||.|.|....|:.:|:..|..|..|.|       |:..:.....||:|..
 Frog   213 IFFFLLSFLLPESPRWLYSHGYTTEAEGVLQSMAVGNGVERP-------VVKLKSCPGTSSKSAH 270

  Fly   352 PIREAFKN--FKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIM 414
            .:.:..|.  .:||.......|.|..||||||:||...|.|:.|.|.|...|||:|.|.:.|..:
 Frog   271 SVFDLVKYGVLRWRTILLMYIWYVCSLVYYGLTLNAGELKGNLYLNVALYGLVEVPAFPLCLYFI 335

  Fly   415 DR--FGRRYSLCGLMLASGLCCIGTIF---TGAD--QPVLQLVLFLVGKLTITASFQVLYFFASE 472
            ::  .|||.:..|.:..:|..||.|||   |..|  .|.   ||.|.|||:::|:|.|:|.:.||
 Frog   336 EKSWSGRRKATAGFLGFAGFACIFTIFLPETNGDLLNPT---VLALFGKLSVSAAFNVVYIYTSE 397

  Fly   473 IYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVL 537
            :|||.:||:.|..|:|..|||.:|:|..|.:.....:.|.:.|..:.|.:|:|:|..|||.|..:
 Frog   398 LYPTVVRNAGLGVCAMACRFGGILSPFIPTMKSLNPSMPFVAFGISGISAGILSLLLPETRNKPI 462

  Fly   538 PTTVQEADAIGVKKQSKSKDL 558
            ..::::..:...:..|:..::
 Frog   463 AESIEDLQSPAYQLLSRGNEV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	118/402 (29%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:475125	131/464 (28%)