Protein Alignment SLC22A and Slc22a16

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_081848.1
• Gene: Slc22a16 / 70840
• MGIID: 1918090
• Length: 649
• Species: Mus musculus
• Alignment Length: 573
• Identity: 142/573 - (24%)
• Similarity: 255/573 - (44%)
• Gaps: 70/573 - (12%)

  Fly    23 EDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCS------------- 74
            |...::.|..|:|.|||||::::|:.....:...:..::.||.:....|.|.
Mouse     2 ESCNVELIFDHIGHFGRFQIVLYLICAYQSLSCGIHYLSSVFLSIIPEHACKPPGMVRKAVFHNV 66

  Fly    75 ----VEECDLPGSNYYEPHTNWSIPKNGK--DLDSCNRYTNSELPQWNHSVDICSADHF-TKNKE 132
                :|:.....|..::.|....: ::|:  :|..|:|       .|..:......::. .|:..
Mouse    67 SAWRLEDILALRSPEHKDHIMVEL-QDGEIWELTRCSR-------TWRENTSHLGYEYSGYKHDS 123

  Fly   133 AC----AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSI 193
            .|    .:::..:|:..|   .:|.:.||.:|...|:..:...|...|.....:::||:||..::
Mouse   124 PCFDGYVYDQSKWRNSAV---RNFNLVCDQKWYARMIQPLIIFGVMLGSITFSYLSDRFGRRMAL 185

  Fly   194 ALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFY 258
            ....|.....|:...|...|..|::..|...|.||..:...||..:|::|.|.|..|...:..|:
Mouse   186 WCTSIGVFFFGIASLFIFDYLSFMITRFFLVMASSGYFVVVFVYVMEIIGKKARTWASIHLNTFF 250

  Fly   259 AVGEVLLAMSAKAFHDW---RILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAA 320
            |:|.:|:|:::.....|   :|:|.|...|.::..   |:|||:..||||:|:.:.|:..:...|
Mouse   251 AIGAMLVALASYLLKTWWLYQIILCIVTTPFILCC---WMLPETPFWLLSEGRYKEAQGTVDTMA 312

  Fly   321 HVNKRELPESVLDKLVLANRDKLQQSSESRFPIR-----EAFKNFKWRIANCSLC----WIVHVL 376
            ..||    .|..|.:.|.:.|..:..::|...||     :.|.|..  :|..:|.    |....|
Mouse   313 VWNK----SSSCDLVELLSLDVTRSHNKSPHSIRKHRLADLFHNLD--VAKMTLIVWLDWFTANL 371

  Fly   377 VYYGLSLNVVLLDGDKYNNFAYIALV---EIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTI 438
            .||.....|:   ..|.|...|:.||   |||.:....:.:.|.|||.::...:|.|.|.|:..:
Mouse   372 GYYMFGKEVI---RRKENEPLYLLLVGAMEIPAYICLCIWLKRVGRRKTMLLFLLVSSLTCMLHV 433

  Fly   439 FTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLL 503
            ...:|....:.::.|:.|..|::.|..:|.:.:|:|||.:|...:...:|:....|:..|.|...
Mouse   434 VMPSDYKTAKRMVALLVKSVISSVFAFIYLYTAELYPTTVRCLAVGSSNMVSHVSSIFIPFTSHF 498

  Fly   504 AKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVL----PTTVQEA----DAIG 548
            :|.:...|.:||...||:||||:|..|||.:..:    .||.|:.    |::|
Mouse   499 SKVWIFLPQILFGILAILSGLLSLKLPETQDTPMKSTWETTEQQVPENKDSLG 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	110/408 (27%)
Slc22a16	NP_081848.1	MFS_SLC22A16_CT2	118..525	CDD:340933	112/421 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	530..560		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..649