DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and LOC685081

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_008764922.2	Gene:	LOC685081 / 685081	RGDID:	1583222	Length:	621	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	164/552 - (29%)
Similarity:	259/552 - (46%)	Gaps:	39/552 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT---- 90
            ::..:|.||.||:.:.:|:.:|....|.|..:.||......|.|||        ::.:.||
  Rat     7 VMAEVGDFGPFQVRVTILMGIPNFLSAFFVFSQVFMVLDEAHHCSV--------SWVKNHTFNLS 63

  Fly    91 -----NWSIPKN--GKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTI 148
                 ..|||.:  |:. :||..:...  |......||.|  |.....:||........:...::
  Rat    64 AAEQLAVSIPNDTAGRP-ESCLMFRPP--PDSASLEDILS--HRFNETQACDSGWDYPENRPPSL 123

  Fly   149 SNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSY 213
            .|:|.:.|:.|.......::...|...|..:.|.|.|..||..||.|..:|..:.||..:|.||:
  Rat   124 KNEFDLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRASILLQVLLSGITGVATAFVPSF 188

  Fly   214 GWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRIL 278
            ..::|..|...:..:....:..::..|.|||..|..|..:....:|:|.:.||..|....:||:|
  Rat   189 ELYMVLCFFSAIAVAGYMMSTMILVSEWVGPSWRTRAMVLAQSNFALGLMALAGLAYGVRNWRLL 253

  Fly   279 LRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKL 343
            ..|...|..:|:.|||:||||.|||||||:.|.||.::::||.||.|.|...:|::||   .:|.
  Rat   254 QIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLASELLNQLV---PEKT 315

  Fly   344 QQSSESRFPIREAFKNFKWRIANCSL--CWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPG 406
            ..|..:    .:.|::.:.|.....|  .|.|..|:||||...|.....|.|.......:||:|.
  Rat   316 GPSGNA----LDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGDFGLDIYLTQVIFGVVEVPA 376

  Fly   407 FFMPLLIMDRFGRRYS-LCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFA 470
            ....:.:|::.||::| ||.|.|| |:.|:..||...|.|.:...|.:|||...:|:|.:.|.:.
  Rat   377 RLSSIPMMEKLGRKWSQLCTLTLA-GVMCVIIIFIPGDLPTVATALAVVGKFASSAAFTISYVYT 440

  Fly   471 SEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNV 535
            :|:.||.:|.:.:...|:..|.|.::.|...||.:|:...|.::|....|.:|||....|||...
  Rat   441 AELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGSLPIGAGLLCALLPETRGQ 505

  Fly   536 VLPTTVQEADAIGVKKQSK----SKDLDLVVT 563
            .|..|:|:.:..|...:.:    |.|..|.||
  Rat   506 TLKDTLQDLEQGGPHGEHRLLGLSLDPGLPVT 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	156/518 (30%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	122/386 (32%)
LOC685081	XP_008764922.2	2A0119	12..510	CDD:273328	156/518 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030