DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Slc22a16

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_038955098.1	Gene:	Slc22a16 / 682934	RGDID:	1592810	Length:	852	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	134/587 - (22%)
Similarity:	253/587 - (43%)	Gaps:	80/587 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGS---N 84
            |...::.|..|:|.|||||:.::|:.....:...:..::.||.:....|.|..     ||:   .
  Rat     2 ESCNVELIFDHVGHFGRFQIALYLICAYQSISCGIHFLSSVFMSIIPEHACKP-----PGTVRKA 61

  Fly    85 YYEPHTNWSI--------PKNGKD-------------LDSCNRYTNSELPQWNHSVDICSADHFT 128
            .:...:.|.:        |:: ||             |..|:|       .|..:......::..
  Rat    62 VFRNVSAWRLEDILALRSPEH-KDHIMVELHDGEIWELTRCSR-------TWRENTSHLGYEYSG 118

  Fly   129 KNKEACAHNEFVFRDDE--VTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSF 191
            ..:::...:.:::...:  .::...|.:.||.:|..:|:..:.......|.....:::||:||..
  Rat   119 YKRDSPCSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRV 183

  Fly   192 SIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITV 256
            ::....|.....|:...|...|..|:...|...||||..:...||..:|.:|.:.|..|...:..
  Rat   184 ALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNT 248

  Fly   257 FYAVGEVLLAMSAKAFHDW---RILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRR 318
            |:|:|.:|:|:.:.....|   :|:|.....|.::..   |:|||:..||||:|:.:.|:.::..
  Rat   249 FFAIGTMLVALVSYLVKTWWLYQIILWTVTAPFILCC---WMLPETPFWLLSEGRYKEAQGVVDA 310

  Fly   319 AAHVNKRELPESVLDKLVLANRDKLQQSSES-----RFPIREAFKN--------FKWRIANCSLC 370
            .|..||    .|..|.:.|.:.|..:...:|     :..:.:.|:|        ..|      |.
  Rat   311 MAVWNK----SSSCDLIELLSLDVTRSHDKSHKGAGKPSLGDLFRNPDIAKMTLIVW------LD 365

  Fly   371 WIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCI 435
            |....|.||..::..|.....::..:..:..||||.:....:.|.|.|||.::...:|.|...|:
  Rat   366 WFTVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICV 430

  Fly   436 GTIFTGADQPVLQ-----LVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSM 495
            ..:...:|....:     :.||:  |:.:.:.|..:|.:.:|:|||.:|...:...:|:....||
  Rat   431 VYVVIPSDSDTAKEAKGAVALFV--KVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASM 493

  Fly   496 LAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKD-LD 559
            :.|.:...:|.:...|.:||...||:||||:|..|||.|..:.:|.:..:    ::..::|| ||
  Rat   494 VIPLSQHFSKVWIFLPQILFGTLAILSGLLSLNLPETQNRPMISTWETTE----EQVPENKDSLD 554

  Fly   560 LV 561
            .|
  Rat   555 KV 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	125/551 (23%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	100/404 (25%)
Slc22a16	XP_038955098.1	MFS	118..528	CDD:421695	100/424 (24%)
Slc22a16	XP_038955098.1	PHA03169	645..>852	CDD:223003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010