Protein Alignment SLC22A and SLC22A5

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 156/569 - (27%)
• Similarity: 275/569 - (48%)
• Gaps: 55/569 - (9%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNW 92
            |.:...||::|.||.:||.|:...::.:....::.||..||..|||.|.:    .:|......|.
Human     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPD----AANLSSAWRNH 65

  Fly    93 SIP---KNGKDL-DSCNRY-------------------------TNSELPQWNHSVDICSADHFT 128
            ::|   ::|::: .||.||                         ..|.|..|..|.|:..:...|
Human    66 TVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVT 130

  Fly   129 KNKEACAHNEF---VFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRS 190
            : :::.|:|..   :.:...:.:...:.:.|:|:||..:..::..:|...|..|.|.::||:||.
Human   131 E-QDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 194

  Fly   191 FSIALGGILGAVLGV------IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVL 249
                  .:|...:|:      ::.||.::..|:|...|..|...:.|...||:|.|::|...|::
Human   195 ------NVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRII 253

  Fly   250 ACSV-ITVFYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAK 313
            ..:: :.:|||.|.::|.:.|....|||:||.....|.::.:|.:|.:|||.|||:|||:.|.|:
Human   254 FSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAE 318

  Fly   314 NILRRAAHVNKRELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCS--LCWIVHVL 376
            .|:|:||..|...:|.::.|...|.:....:|.|.:   |.:..:.:..|:....  :.|:...:
Human   319 VIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHN---ILDLLRTWNIRMVTIMSIMLWMTISV 380

  Fly   377 VYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTG 441
            .|:||||:...|.||.:.|....|:||:|.:.:..|::....||||:...:...|...:......
Human   381 GYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVP 445

  Fly   442 ADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKY 506
            .|...|..||.:|||..:||:|.::|.:.:|:|||.:||..:...|...|.||:|:|....|..|
Human   446 PDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAY 510

  Fly   507 YANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKS 555
            ....|.:|.....|::.:||||.||:....||.|:.:...:...|..|:
Human   511 DRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKT 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	117/405 (29%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	151/545 (28%)