Protein Alignment SLC22A and SLC22A4

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 152/553 - (27%)
• Similarity: 277/553 - (50%)
• Gaps: 44/553 - (7%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNW 92
            |.::..||::|.||.:||.|:...::.:....::.||.|.|..|||.|.:    .:|......|.
Human     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPD----AANLSSAWRNN 65

  Fly    93 SIP---KNGKDL-DSCNRYTNSELPQWN-------HSVDICSADHFTKNKEACAHNEFVFRDDEV 146
            |:|   ::|::: .||:||..:.:..::       ..||:...:     :|:|. :.:.|..|..
Human    66 SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLE-----QESCL-DGWEFSQDVY 124

  Fly   147 --TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV---- 205
              |:..::.:.|:|.||:.:..::..:|...|..:.|.::||:||.      .:|.|.:.|
Human   125 LSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRK------NVLFATMAVQTGF 183

  Fly   206 --IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVFYAVGEVLLAM 267
              ::.||.|:..|.|...:..|...:.|...|::|.|::|...|::..:: :..|:|||.:||.:
Human   184 SFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPL 248

  Fly   268 SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVL 332
            .|....|||:||.....|.::.:..:|.:|||.|||:||.:...|::|:::||.:|...:|..:.
Human   249 FAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIF 313

  Fly   333 DKLVLANRDKLQQSSESRFPIREAF--KNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNN 395
            |.:     ::|....:.:..|.:.|  :|.........|.|::..:.|:.|||:...|.||.|.|
Human   314 DSV-----EELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLN 373

  Fly   396 FAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTIT 460
            ....||:|||.:....|::....|||.:..::...|...:.......|...|.:.|.::||..||
Human   374 CFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGIT 438

  Fly   461 ASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLL 525
            ::|.:||.|.:|:|||.:||..:...|...|.||::||....|..|....|.::.....::.|:|
Human   439 SAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGIL 503

  Fly   526 TLFFPETTNVVLPTTVQEADAI-GVKKQSKSKD 557
            ||||||:..:.||.|:::...: ..:...|::|
Human   504 TLFFPESLGMTLPETLEQMQKVKWFRSGKKTRD 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	114/404 (28%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	147/526 (28%)