Protein Alignment SLC22A and SLC22A2

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 167/559 - (29%)
• Similarity: 262/559 - (46%)
• Gaps: 37/559 - (6%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC---SVEECDLPGSNYYE 87
            |:|.:|:|.|:|..||..:|.|:.|.....|...|..||...|..|||   .|.|..|.......
Human     4 TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPA 68

  Fly    88 PHTNWSIPKNGKDLDS----CNRYTNSELPQWNHSVDIC-----SADHFTKNKEAC----AHNEF 139
            ...|:::|..|...::    |.||.    ..||.|...|     |.|   .|:...    ..:.:
Human    69 EELNYTVPGPGPAGEASPRQCRRYE----VDWNQSTFDCVDPLASLD---TNRSRLPLGPCRDGW 126

  Fly   140 VFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLG 204
            |:.....:|..:|.:.|.:.|.|.:..:..|:|.|.|....|::|||:||...:....::.|..|
Human   127 VYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAG 191

  Fly   205 VIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSA 269
            |:.:.||:|.|.|:|..:..:.|...:...:::..|.||.:.|........|.|.||.::||..|
Human   192 VLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVA 256

  Fly   270 KAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDK 334
            .|...||.|......|:...|.|:|.:|||.|||:||.|...|..|::..|..|.:.||.| |.:
Human   257 YALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPAS-LQR 320

  Fly   335 LVLANR--DKLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFA 397
            |.|...  .||..|........:..|:....:.|    |....::|.||.:::.|...:.|.:|.
Human   321 LRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYN----WFTSSVLYQGLIMHMGLAGDNIYLDFF 381

  Fly   398 YIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITAS 462
            |.||||.|..||.:|.:||.||||......:.:|..|:.::|...|...|::::..:|::.||.:
Human   382 YSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMA 446

  Fly   463 FQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYAN----APAMLFAGAAIVSG 523
            ::::....:|:|||.:||..:..||.|...|.::   ||.|.....|    .|.|:|....:|:|
Human   447 YEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII---TPFLVYRLTNIWLELPLMVFGVLGLVAG 508

  Fly   524 LLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVV 562
            .|.|..|||....||.|::||:.:...:::|.|.:.|.|
Human   509 GLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQV 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	156/526 (30%)
		MFS	146..530	CDD:119392	119/389 (31%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	156/526 (30%)
		MFS	124..492	CDD:119392	113/375 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030