Protein Alignment SLC22A and SLC22A3

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 171/577 - (29%)
• Similarity: 268/577 - (46%)
• Gaps: 97/577 - (16%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVF-------------TAATVTHRCSVEE 77
            :.|..|:.:|:|||||..:|||:||..:..|...|..||             :||.:..||.
Human     3 SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCG--- 64

  Fly    78 CDLPGSNYYEPHTNWSI-------PKNGKDLDSCNRYTNSELPQWNHSVDICS----ADHFT--K 129
                    :.|...|:.       |:..:....|.||.   |...|.|....|    ||...  .
Human    65 --------WSPEEEWNRTAPASRGPEPPERRGRCQRYL---LEAANDSASATSALSCADPLAAFP 118

  Fly   130 NKEA----C--------AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGF 182
            |:.|    |        ||:         ||.::|.:.|.:.|.|.:...|.|||...|....|:
Human   119 NRSAPLVPCRGGWRYAQAHS---------TIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGY 174

  Fly   183 VADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRR 247
            .||||||.....|..:...|.||:.:|:|::..|::|.||..:.....:.||:||..|:||.|:|
Human   175 AADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQR 239

  Fly   248 VLACSVITVFYAVGEVLLAMSAKAFHDWR-ILLRITYGPSLILLAYFWILPESVRWLLSQGKEER 311
            .:...||.:|:.:|.::|...|....:|: |.|.||. ||.:.|.|:|::|||.|||:::.|.::
Human   240 RIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITL-PSFLFLLYYWVVPESPRWLITRKKGDK 303

  Fly   312 AKNILRRAAHVNKRELPESVLDKLVLANRDKLQQSSES----------RFPIREAFKNFKWRIAN 366
            |..||||.|..|         .|.:.:|..::..:.|.          |.|          ::..
Human   304 ALQILRRIAKCN---------GKYLSSNYSEITVTDEEVSNPSFLDLVRTP----------QMRK 349

  Fly   367 CSL----CWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLM 427
            |:|    .|....:||.||.:.:.::.|:.|.:|....:||:||..:.||.::|.|||.......
Human   350 CTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASN 414

  Fly   428 LASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRF 492
            :.:|:.|:.|.|.......|:..:..:|:|.||.:|:::|...||:|||.|||..:|.||.:..|
Human   415 IVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDF 479

  Fly   493 GSMLAPQTPL-LAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIG 548
            |.::||.... ||..:...|.::|...|.:.|.|.:..|||..:.||.||.:.:.:|
Human   480 GGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLG 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	166/558 (30%)
		MFS	146..530	CDD:119392	125/399 (31%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	166/558 (30%)
		MFS	149..518	CDD:119392	121/388 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960