Protein Alignment SLC22A and SLC22A1

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 161/524 - (30%)
• Similarity: 237/524 - (45%)
• Gaps: 40/524 - (7%)

  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT 90
            |:|.||:.:|:.|.||...||::||.....|...|..||...|..|     .|..||........
Human     3 TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDH-----HCQSPGVAELSQRC 62

  Fly    91 NWS--------IPKNGKD----LDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAH------- 136
            .||        :|..|..    |..|.||.    ..||.|...| .|.........:|
Human    63 GWSPAEELNYTVPGLGPAGEAFLGQCRRYE----VDWNQSALSC-VDPLASLATNRSHLPLGPCQ 122

  Fly   137 NEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL-G 200
            :.:|:.....:|..:|.:.|.|.|||.:..:..|.|..||....|:.|||:||...: ||.:| .
Human   123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL-LGTVLVN 186

  Fly   201 AVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLL 265
            ||.||:.:|||:|...|:|..|..:.|...:...:.:..|.||...|.....:..:.:.||.|.|
Human   187 AVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVAL 251

  Fly   266 AMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPES 330
            ...|.|...||.|......|:.:.|.|:|.:|||.||||||.:...|..|:...|..|.: ||.:
Human   252 TGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK-LPPA 315

  Fly   331 VLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCSL--CWIVHVLVYYGLSLNVVLLDGDKY 393
            .| |::....|..::.|.|   ..:.|:..:.|.....|  .|....::|.||.|::....|:.|
Human   316 DL-KMLSLEEDVTEKLSPS---FADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLY 376

  Fly   394 NNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLT 458
            .:|.|.|||||||.|:.|:.:||.||.|.:....|.:|..|:..||...|...|.:::..||::.
Human   377 LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMG 441

  Fly   459 ITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPL-LAKYYANAPAMLFAGAAIVS 522
            ||.:.|::....:|:|||.:||..:..||.:...|.::.|.... |.:.:...|.:|| |.....
Human   442 ITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILF-GQRTSK 505

  Fly   523 GLLT 526
            .|||
Human   506 TLLT 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	127/402 (32%)
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	153/504 (30%)