Protein Alignment SLC22A and Slc22a23

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_072146.1
• Gene: Slc22a23 / 64559
• RGDID: 620302
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 138/642 - (21%)
• Similarity: 236/642 - (36%)
• Gaps: 163/642 - (25%)

  Fly     4 SEAPPADPAVEVAPPAKDSEDVTLD---AILKHLGQF-GRFQLIIFLLICLPMMF--HAMFSVTY 62
            |..|.:......|.|:.    :.||   ::|..||.. |.:|..:.:|..:|.:|  .:.||.::
  Rat    59 SGGPHSSCCAAAAAPSL----LLLDYDGSVLPFLGGLGGGYQKTLVVLTWIPALFIGFSQFSDSF 119

  Fly    63 V----------------FTAATVTHRCSVEECDLPGSNYYEPH------TNWSIPKN-------- 97
            :                ...||||.|..    |:  .|:..|.      .:|....|
  Rat   120 LLDQPNFWCHGAGKGTELAGATVTGRWG----DM--GNWTSPSATPFSTASWGTTSNRSNSSDTP 178

  Fly    98 ------GKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISNDFGIFC 156
                  ||.    |..:|.|...|::.:           :.....|          :.:.:.:.|
  Rat   179 PLPSPPGKG----NNDSNCECHAWDYGI-----------RTGLVQN----------VVSKWDLVC 218

  Fly   157 DDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEF 221
            |:.||:.:......:|..||..|.|.:||..||...:....|...:.|:..:.|.:...|....|
  Rat   219 DNAWKVHVAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSVIFILIFGLTVALSVNVTMFSTLRF 283

  Fly   222 LDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRITYGPS 286
            .:....:.:..|.:.:.|||..|.:|.:...|.:.....|:.|:...|....||::|..:...|.
  Rat   284 FEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPF 348

  Fly   287 LILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQSSESRF 351
            |::|.|:.|.|||:|||::..:.|.||.::......|... |||.: |.|:...:|    ..||.
  Rat   349 LLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQKNCVS-PESDI-KGVMPELEK----ELSRR 407

  Fly   352 P----------IREAFKNFKWRIANCSLCWIVHVLVYYGL-----------SLNVVLLDGDKYNN 395
            |          .|..:||.      ..||  |:.|..||:           .:.|.||: :.|.:
  Rat   408 PKKVCIVKVVGTRNLWKNI------VVLC--VNSLTGYGIHHCFARSMMGHEVKVPLLE-NFYAD 463

  Fly   396 FAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQL-VLFLVGKL-- 457
            :..:|.:.:.......|::...|||..|...|:.:.|..:           ||| :|.|:||.
  Rat   464 YYTMASIALASCLAMCLVVRFLGRRGGLLLFMILTALASL-----------LQLGLLNLIGKYSQ 517

  Fly   458 ----------------TITASFQVLY----------------FFASEIYPTNLRNSLLSFCSMMG 490
                            ::...|.:.:                ||.:||.||.:|...|.......
  Rat   518 HPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASA 582

  Fly   491 RFGSMLAPQTPLLAK--YYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEAD 545
            .||.:.||...|..:  |:.:  .::||...::..:..|..||:.:..||..:...:
  Rat   583 GFGMLTAPIIELHNQKGYFLH--HIIFACCTLICIICILLLPESRDQNLPENIANGE 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	130/601 (22%)
		MFS	146..530	CDD:119392	101/441 (23%)
Slc22a23	NP_072146.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..188		4/29 (14%)
		MFS_SLC22A23	187..608	CDD:341002	103/473 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100