DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Sv2b

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001103223.1	Gene:	Sv2b / 64176	MGIID:	1927338	Length:	683	Species:	Mus musculus

Alignment Length:	696	Identity:	129/696 - (18%)
Similarity:	215/696 - (30%)	Gaps:	267/696 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VAPPAKDSEDVT--LDAILKHLGQFGRFQLIIFLLICLPMMFHA--MFSVTYVFTAATVTHRCSV 75
            :|...:|.|::.  .:.|:...|. ||||..:|.::.|.:|...  :|.|::
Mouse    81 MAERMEDEEELAHQYETIIDECGH-GRFQWTLFFVLGLALMADGVEIFVVSF------------- 131

  Fly    76 EECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFV 140
                             ::|...||:
Mouse   132 -----------------ALPSAEKDM--------------------------------------- 140

  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205
                           |....|..|:|.|..||...|..|.|.:||:.||...:::...:.|....
Mouse   141 ---------------CLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFAS 190

  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAK 270
            :.||...||.||....:..:.........|....|.:..::|....|.:.:|:..|.:..:..|.
Mouse   191 LSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAW 255

  Fly   271 A----------------FHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRA 319
            :                ||.||:.:.:...|:.:.:.....:|||.|:||..||.:.|..||::.
Mouse   256 SIIPHYGWGFSMGTNYHFHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQV 320

  Fly   320 AHVNKRE--LPESV-----------LDKLVLANRDKLQQSSES---RFPIR--EAFKN------- 359
            ...|.|.  .||.|           :|:.:     ::|.|:.:   |:.:|  ..||.
Mouse   321 HDTNMRAKGTPEKVFTVSHIKTPKQMDEFI-----EIQSSTGTWYQRWLVRFMTIFKQVWDNALY 380

  Fly   360 -----FKWRIANCSLCWIVHVLVYYGL-------------------------------SLNVVL- 387
                 ::......::.|....|.||||                               ::|..:
Mouse   381 CVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTME 445

  Fly   388 --------LDGDK-----------------------------------------YNNFAY----- 398
                    |..||                                         ||...|
Mouse   446 NQIHQHGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFI 510

  Fly   399 ---------------------------IALVE-------IPGFFMPLLIMDRFGRRYSLCGLMLA 429
                                       |.||.       :||..:..|:|||.||...:.|.||.
Mouse   511 NCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLI 575

  Fly   430 SGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGS 494
            |.:||....|..::..::.......|  |..|::..|.....|:||||.|.:.....:.:.:||:
Mouse   576 SAVCCFFLFFGNSESAMIGWQCLFCG--TSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGA 638

  Fly   495 MLAPQTPLLAKYYA---NAPAMLFAGAAIVSGLLTLFFPETTNVVL 537
            :|.  ..:.|.:..   ..|.:|.|.:.:..||:.|..|||...||
Mouse   639 ILG--NTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVL 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	125/674 (19%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	107/552 (19%)
Sv2b	NP_001103223.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
Sv2b	NP_001103223.1	synapt_SV2	8..683	CDD:130366	129/696 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910