DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and Sv2a

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_071313.1	Gene:	Sv2a / 64051	MGIID:	1927139	Length:	742	Species:	Mus musculus

Alignment Length:	707	Identity:	136/707 - (19%)
Similarity:	218/707 - (30%)	Gaps:	261/707 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAASEAPPADPAVEVAPPAKDSEDVT--LDAILKHLGQFGRFQLIIFLLICLPMMFHA--MFSVT 61
            ::..|.||....  .|...||.|::.  .:.||:..|. ||||..::.::.|.:|...  :|.|.
Mouse   126 LSDGEGPPGGRG--EAQRRKDREELAQQYETILRECGH-GRFQWTLYFVLGLALMADGVEVFVVG 187

  Fly    62 YVFTAATVTHRCSVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADH 126
            :|..:|                                                  ..|:|.:|
Mouse   188 FVLPSA--------------------------------------------------EKDMCLSD- 201

  Fly   127 FTKNKEACAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSF 191
              .||                               .|:|.|..||...|..:.|.:|||.||..
Mouse   202 --SNK-------------------------------GMLGLIVYLGMMVGAFLWGGLADRLGRRQ 233

  Fly   192 SIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITV 256
            .:.:...:.:|.....||...||.||....|..:.........|....|.:..::|....|.:.:
Mouse   234 CLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCM 298

  Fly   257 FYAVGEVLLAM----------------SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLS 305
            |:.:|.|..|.                ||..||.||:.:.:...||:..:......|||.|:.|.
Mouse   299 FWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLE 363

  Fly   306 QGKEERAKNILRRAAHVNKREL--PESVLD----KLVLANRDKLQQSSES-----RFPIR----- 354
            .||.:.|..:|::....|.|..  ||.|..    |.:....:.::..|::     |:.:|
Mouse   364 NGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLG 428

  Fly   355 -EAFKNF------KWRIANCSL--CWIVHVLVYYGLS---------------------------- 382
             :.:.||      ::|.....:  .|......||||:
Mouse   429 GQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVE 493

  Fly   383 ----------------------------------------------------------LNVVLLD 389
                                                                      :|.|..:
Mouse   494 HVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYN 558

  Fly   390 GD----KYNNF------------------------AYI--------ALVEIPGFFMPLLIMDRFG 418
            .|    |:.|.                        ||:        .|..:||..:..|:||:.|
Mouse   559 TDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIG 623

  Fly   419 RRYSLCGLMLASGLCCIGTIFT--GADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNS 481
            |...|.|   :|.|.|:...|.  |..:..:..:|.|.|.::| ||:..|.....|:||::.|.:
Mouse   624 RLRMLAG---SSVLSCVSCFFLSFGNSESAMIALLCLFGGVSI-ASWNALDVLTVELYPSDKRTT 684

  Fly   482 LLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSG-LLTLFFPETTNVVL 537
            ...|.:.:.:..::|.............|..:|||.||:..| .|.|..|||...||
Mouse   685 AFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	127/671 (19%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	106/549 (19%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	136/707 (19%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..145		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910