Protein Alignment SLC22A and SLC22A23

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_011513103.1
• Gene: SLC22A23 / 63027
• HGNCID: 21106
• Length: 710
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 142/644 - (22%)
• Similarity: 241/644 - (37%)
• Gaps: 144/644 - (22%)

  Fly     7 PPADP---------AVEVAPPAKDSEDVTLD---AILKHLGQF-GRFQLIIFLLICLPMMF--HA 56
            ||..|         :...||..     :.||   ::|..||.. |.:|..:.||..:|.:|  .:
Human    54 PPLHPGGGPHPSCCSAAAAPSL-----LLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFS 113

  Fly    57 MFSVTYVFTAATVTHRCSVEECDLPG---SNYYEPHTNW-SIP-----------------KNGKD 100
            .||.:::........|.:.:..:|.|   :.......|| |:|                 .:|.|
Human   114 QFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGAD 178

  Fly   101 ----------LDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISN----- 150
                      .|..:..:|.:...|::.:......:..  .:.|...|......:.....
Human   179 GGDTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVV--SKCCQQQETGALPWDTDTKRWRPEL 241

  Fly   151 DFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGW 215
            ::.:.||:.||:.:......:|..||..|.|.:||..||...:....|...:.|:..:.|.:...
Human   242 NWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTM 306

  Fly   216 FLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLR 280
            |....|.:....:.:..|.:.:.|||..|.:|.:...|.:.....|:.|:...|....||::|..
Human   307 FSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQA 371

  Fly   281 ITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQ 345
            :...|.|::|.|:.|.|||:|||::..:.|.||.::......|:.. ||..: |.|:...:|
Human   372 LIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMN-PEGDI-KGVIPELEK--- 431

  Fly   346 SSESRFP----------IREAFKNFKWRIANCSLCWIVHVLVYYGL-----------SLNVVLLD 389
             ..||.|          .|..:||.      ..||  |:.|..||:           .:.|.||:
Human   432 -ELSRRPKKVCIVKVVGTRNLWKNI------VVLC--VNSLTGYGIHHCFARSMMGHEVKVPLLE 487

  Fly   390 ---GDKYNNFAYIALVEIPGFFMPLLIMDRF-GRRYSLCGLMLASGLCCIGTIFTGADQPVLQL- 449
               .|.|.. |.||||..    :.:.::.|| |||..|...|:.:.|..:           |||
Human   488 NFYADYYTT-ASIALVSC----LAMCVVVRFLGRRGGLLLFMILTALASL-----------LQLG 536

  Fly   450 VLFLVGKL----------TITASFQVLY----------------FFASEIYPTNLRNSLLSFCSM 488
            :|.|:||.          ::...|.:.:                ||.:||.||.:|...|.....
Human   537 LLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLA 601

  Fly   489 MGRFGSMLAPQTPLLAK--YYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEAD 545
            ...||.:.||...|..:  |:.:  .::||...::..:..|..||:.:..||..:...:
Human   602 SAGFGMLTAPIIELHNQKGYFLH--HIIFACCTLICIICILLLPESRDQNLPENISNGE 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	133/597 (22%)
		MFS	146..530	CDD:119392	106/442 (24%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	109/440 (25%)
		MFS	259..>388	CDD:119392	32/128 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010