Protein Alignment SLC22A and sv2a

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_696434.2
• Gene: sv2a / 568033
• ZFINID: ZDB-GENE-131001-1
• Length: 733
• Species: Danio rerio
• Alignment Length: 693
• Identity: 134/693 - (19%)
• Similarity: 212/693 - (30%)
• Gaps: 270/693 - (38%)

  Fly    20 KDSEDVT--LDAILKHLGQFGRFQLIIFLLICLPMMFHA--MFSVTYVFTAATVTHRCSVEECDL 80
            ||.|::.  .:.||:..|. ||||..::.::.|.:|...  :|.|.:|
Zfish   135 KDQEELAQQYETILQECGH-GRFQWTLYFVLGLALMADGVEIFVVGFV----------------- 181

  Fly    81 PGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDE 145
                         :|...||:
Zfish   182 -------------LPSAEKDM-------------------------------------------- 189

  Fly   146 VTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFS 210
                      |..|....|:|.|..||...|..:.|.:|||.||..::.:...:.:|.....||.
Zfish   190 ----------CLSEPNKGMLGLIVYLGMMVGAFVWGGLADRIGRRQTLLISLSINSVFAFFSSFV 244

  Fly   211 PSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAM-------- 267
            ..|..||....|..:.........|....|.:..::|....|.:.:|:.:|.:..|.
Zfish   245 QGYSSFLFCRLLSGVGIGGSIPIVFSYYSEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPH 309

  Fly   268 --------SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNK 324
                    ||..||.||:.:.:...||:..:|....:|||.|:.|..||.:.|..||::....|.
Zfish   310 YGWSFQMGSAYQFHSWRVFVLVCAFPSVAAIAALTTMPESPRFYLENGKHDEAWMILKQVHDTNM 374

  Fly   325 RE--LPESV-----------LDKLV----------------LAN--------------------- 339
            |.  .||.|           :|:||                |.|
Zfish   375 RAKGYPERVFSVTTIKTVKQMDELVDMGGEATAWHQRWRIKLTNLFHQVWGNFLTVFNPEYRRIT 439

  Fly   340 ---------------------------RDKLQQSSESRFPIREA--------------------- 356
                                       ..|.:.||.::..|:|.
Zfish   440 YMMMAVWFSMSFSYYGLTVWFPDMIKYLQKQEYSSRTKVFIKEKVEHVTFNFTLENQIHRNGEYF 504

  Fly   357 ---------------------------------FKN-------------FKWRIANCSL--CWIV 373
                                             |:|             ||:|:.|..|  ...:
Zfish   505 NNKFLNLKMKSMVFEDSLFEECYFEDITSSNTFFRNCTFISTLFYNTDLFKYRLINSKLINSTFL 569

  Fly   374 HVLVYYGLSLNVVLLDGDKYNNFAYI--------ALVEIPGFFMPLLIMDRFGRRYSLCGLMLAS 430
            |       :....:||....|| ||:        .|..:||..:..|:||:.||...|.|..:.|
Zfish   570 H-------NKEGCMLDFSDENN-AYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVIS 626

  Fly   431 GLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSM 495
            .:.|....|..::..::.| |.|.|.::| ||:..|.....|:||::.|.:...|.:.:.:..::
Zfish   627 CVSCFFLSFGNSESAMIAL-LCLFGGISI-ASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAV 689

  Fly   496 LAPQTPLLAKYYANAPAMLFAGAAIVSG-LLTLFFPETTNVVL 537
            |.............|..:|||..|:.:| .|.|..|||...||
Zfish   690 LGISIFQSFVGITKAVPILFASGALAAGSFLALKLPETRGQVL 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	111/564 (20%)
sv2a	XP_696434.2	synapt_SV2	1..733	CDD:130366	134/693 (19%)