Protein Alignment SLC22A and Slc22a21

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_062697.1
• Gene: Slc22a21 / 56517
• MGIID: 1929481
• Length: 564
• Species: Mus musculus
• Alignment Length: 551
• Identity: 158/551 - (28%)
• Similarity: 271/551 - (49%)
• Gaps: 40/551 - (7%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNW 92
            |.:...||::|.||.:||.|:...::.:....::.||..|...|||.:.:.    .|......|.
Mouse     5 DEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIPDT----VNLSSAWRNH 65

  Fly    93 SIPKNGKD----LDSCNRYTNSELPQWN-------HSVDICSADHFTKNKEAC----AHNEFVFR 142
            |||...||    ...|.||..:.:..::       ..||:...:     :|.|    .:::.:|.
Mouse    66 SIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLE-----QENCLDGWEYDKDIFL 125

  Fly   143 DDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIR 207
            .   ||..::.:.|.|:||..:..:...:|...|..|.|.::||:||...:.|...:......|:
Mouse   126 S---TIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMHTGFSFIQ 187

  Fly   208 SFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVFYAVGEVLLAMSAKA 271
            .||.::..|.:...|..|...:.|...||:|.|::....|::..:: :.:|:|.|.::|.:.|..
Mouse   188 VFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVLPLFAYF 252

  Fly   272 FHDW-RILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKL 335
            ..:| |:||.||. |.::..|.:|.:|||.|||:|||:.:.|:.|:|:||.:|....|.::.|.
Mouse   253 IREWRRLLLAITL-PGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDP- 315

  Fly   336 VLANRDKLQQSSESRFP----IREAFKNFKWRIANCS--LCWIVHVLVYYGLSLNVVLLDGDKYN 394
              :..:|||..| |:.|    |.:..:....||....  :.|:...:.|:||||:...|:|:.|.
Mouse   316 --SETNKLQDDS-SKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYV 377

  Fly   395 NFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTI 459
            |...:|.||:|.:.:..|::....||||:.|.:...|...:......:|...|...|.:|||..|
Mouse   378 NCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGI 442

  Fly   460 TASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGL 524
            |:::.::|.:.:|:|||.:||..:...|...|.||:|:|....|..|....|.:|.....|::.:
Mouse   443 TSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAI 507

  Fly   525 LTLFFPETTNVVLPTTVQEADAIGVKKQSKS 555
            :||||||::.|.||.|:.|...:...||.:|
Mouse   508 ITLFFPESSGVSLPETIDEMQKVKKLKQRQS 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	118/401 (29%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	151/527 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..564		3/7 (43%)