Protein Alignment SLC22A and sv2ca

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001121811.1
• Gene: sv2ca / 562345
• ZFINID: ZDB-GENE-060526-233
• Length: 745
• Species: Danio rerio
• Alignment Length: 648
• Identity: 117/648 - (18%)
• Similarity: 205/648 - (31%)
• Gaps: 229/648 - (35%)

  Fly    96 KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEF----VFRDDEVTISNDFGIF- 155
            |:.::|::..:....||.| .:.:.|          :.|.|..|    .|......:|:...:|
Zfish   120 KDRRELENERQADEEELAQ-QYELII----------QECGHGRFQWQLFFTLGLALMSDGVEVFV 173

  Fly   156 ------------CDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRS 208
                        |..:.....:|:|..||...|....|.:||:.||...:.:...|......:.|
Zfish   174 VGFVLPSAETDMCVPDSSSGWLGSIVYLGMMVGAFFWGGMADKVGRRQCLLICMSLNGFFAFLSS 238

  Fly   209 FSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAM------ 267
            |...||.||:...:............|....|::..::|....|.:.:|:.:||:..:.
Zfish   239 FVQGYGLFLLCRMIAGFGIGGAVPIVFSYFAEVLAREKRGEHLSWLCMFWMIGEIYASAMAWAII 303

  Fly   268 ---------------------------SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLS 305
                                       ||..||.||:.:.:...|.:..:.....:|||.|:.|.
Zfish   304 PHYGQITTASSQFINYHHYTSWSFSMGSAYQFHSWRVFVVVCALPCVCAVVALTFMPESPRFYLE 368

  Fly   306 QGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQS--------------SESRFPIREA 356
            .||.:.|..||::....|.|...:.  :|:...||.|:.:.              |::.|.|:..
Zfish   369 VGKHDEAWMILKQIHDTNMRARGQP--EKVFTVNRIKIPKQIDEFVEMHESGNFFSKAIFRIKTE 431

  Fly   357 FKNFKWRIANC------------SLCWIVHVLVYYGLSL---NVVL-LDGDKY------------ 393
            ..........|            ::.|:.....|||||:   :|:. |..|:|
Zfish   432 LHGIWLNFLKCFNYPVKESTVKLAIVWLTLSFGYYGLSVWFPDVIKHLQNDEYASKGQRHNNERI 496

  Fly   394 ------------------------------------------------------NNFAYI----- 399
                                                                  .|..:|
Zfish   497 EDFTFNFTLENQIHTNSLFINDRFINMKFKSVTFINSTFQSCFFEDVTSVGSFFRNCTFIEAVFY 561

  Fly   400 ----------------------------------------------ALVEIPGFFMPLLIMDRFG 418
                                                          .|..:||..:..|:||:.|
Zfish   562 NTDIDDSKLKNTDVINSTFYHNKTGCQMTFEDDYSAYWVYFVNFLGTLAVLPGNIVSALLMDKIG 626

  Fly   419 RRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLL 483
            |...|...|:.||:.|. .::.|..:.::..:|.|...|:|:| :..|....:|:|||:.|.:..
Zfish   627 RLSMLGFSMILSGISCF-FLWFGTSESMMIGMLCLYNGLSISA-WNSLDVVTTELYPTDRRGTGF 689

  Fly   484 SFC-------SMMGR--FGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVL 537
            .||       ::||.  |||::.....:        |.:|.:...:..||:.|..|:|.:.||
Zfish   690 GFCNALCKLAAVMGNLIFGSLVGITKAI--------PILLASSVLVGGGLVGLRLPDTRSNVL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	106/599 (18%)
sv2ca	NP_001121811.1	synapt_SV2	3..745	CDD:130366	117/648 (18%)