Protein Alignment SLC22A and slc22a16

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001020659.1
• Gene: slc22a16 / 557279
• ZFINID: ZDB-GENE-041001-166
• Length: 565
• Species: Danio rerio
• Alignment Length: 560
• Identity: 153/560 - (27%)
• Similarity: 255/560 - (45%)
• Gaps: 36/560 - (6%)

  Fly    27 LDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC----SVEECDLPGSNYYE 87
            ::.:...||.|.|||..::.......:...:..:..||...|....|    ::.:......::..
Zfish     5 VERLFDELGHFKRFQACLYFAAIFQAISCGIHYLASVFLVETPKFLCNPPLNITDVLYKNLSFTS 69

  Fly    88 PHTNWSIPKNGKDLDSCNRYTNSELPQWNHS-------VDICSADH-FTKNKEACAHNEFVFRDD 144
            ....|:..|.|   |.......|:..||..|       :|..:..: |..||...:...||:...
Zfish    70 LADIWTHYKTG---DGPVVVRTSQGDQWELSPCLKALRLDAINFQYEFFGNKSVESCGAFVYDHS 131

  Fly   145 EV--TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIR 207
            ||  :|..|:.:.|:.||...:......||...|..:.|..|||.||...:....:...:.||..
Zfish   132 EVEQSIVTDWDLVCEREWLAKLTQPTFMLGVLIGALMFGDAADRIGRRPVLMATSLCQFIFGVTV 196

  Fly   208 SFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAF 272
            :|:.:|..|:|..||....||......||...|..|.|.|......:...:|||.:::|:.....
Zfish   197 AFTGNYYLFVVMRFLLATVSSGYLVVVFVYVTEFTGIKVRTWTSMHVHAAFAVGIMVVALVGYLV 261

  Fly   273 HDW---RILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESV--- 331
            ..|   :|:|.::..|.|:   |.|..||:..:|:::|:.:.|:.:|...|::|  .||.::
Zfish   262 RVWWIYQIILTLSTSPFLL---YCWKFPETPFYLMAKGRYKEAQELLDTMAYIN--GLPPTLKVS 321

  Fly   332 -----LDKLVLANRDKLQQSSESRFPIREAFKNFKW--RIANCSLCWIVHVLVYYGLSLNVVLLD 389
                 .|:..|.: :|.....|.|..:.:.|.:.|.  |.|.|...|.:..|.||..||..|.|.
Zfish   322 DLQDGCDRTPLKD-NKQAMEVEKRLSMLDMFGSLKMAGRSATCWAIWFIGSLGYYVFSLGSVNLG 385

  Fly   390 GDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLV 454
            |::|.|......||:|.:.:....||||||:.:....:|..|:.|:..|....|..||.:||.:.
Zfish   386 GNQYINLFLAGAVEVPSYLIGCFAMDRFGRKKTCAPALLLGGVACMLIIVVPQDVEVLAIVLSMT 450

  Fly   455 GKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAA 519
            ||..|..:|.::|.:..|:|||.:|:..:...|||.|.||::||....||..:...|.::....|
Zfish   451 GKFAIAIAFGLIYLYTCELYPTIIRSLAVGSGSMMCRVGSVVAPFCVYLADIWIYLPQLIVGILA 515

  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLD 559
            .:.|:||:|.|||....|.:|::||:|:|.|..:|:.:::
Zfish   516 FIIGILTMFLPETLGEPLTSTLEEAEALGSKPNTKNTEVN 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	120/408 (29%)
slc22a16	NP_001020659.1	MFS_SLC22A16_CT2	115..526	CDD:340933	122/416 (29%)