DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and slc22a13b

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_017209322.1	Gene:	slc22a13b / 556601	ZFINID:	ZDB-GENE-061013-532	Length:	549	Species:	Danio rerio

Alignment Length:	512	Identity:	160/512 - (31%)
Similarity:	250/512 - (48%)	Gaps:	16/512 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNY-YEPHTNWS 93
            ||..:|:||.||..:.:.:|||.:|.|......||||.:..|.|:.........|. .|...|.:
Zfish     7 ILSSVGEFGAFQKRLLVAVCLPNIFTAFHMFGQVFTAISFPHYCNSSWILRQAPNLTEEKQLNLT 71

  Fly    94 IPKNGK-DLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFR--DDEVTISNDFGIF 155
            :|.:.| ..:||..:|..|:       ||...:|:..|......:.:|::  .|..|:..:|.:.
Zfish    72 VPLDSKGQYESCKMFTPVEM-------DIEDIEHYGINTTTSCIDGWVYKAPKDSSTLITEFDLV 129

  Fly   156 CDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFE 220
            |:::.......:|...|...|..:.|.:||:|||.|:..|...|..:.||..:|||:...::...
Zfish   130 CENKVYSEASQSIYMAGLLVGALLFGPMADKYGRRFATLLSLFLQFLSGVGVAFSPNIYVYIALR 194

  Fly   221 FLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRILLRITYGP 285
            |:...|.|.:....||:|.|..|..:|.|...:...|:|:|.:||:..|....:||:|..:...|
Zfish   195 FVVGTTISGISINTFVLGTEWCGSAKRALFTILSHCFFAIGLMLLSGVAYGIRNWRVLQLVLSAP 259

  Fly   286 SLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQSSESR 350
            ..:...|:||||||.||||:|||.:.||..:.:||.:|.|::.|::|||:...|..|   ||...
Zfish   260 VGLFFIYYWILPESARWLLTQGKLDSAKREILKAARINGRKVSENLLDKMEAENTAK---SSTMI 321

  Fly   351 FPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMD 415
            ...|..:.. |..:..|.: |.|..|||||:||||.....|.|.......:.|.|.......::.
Zfish   322 DLFRVGYLR-KRALIMCYM-WFVTSLVYYGVSLNVGNFGLDIYLTQLIFGMAEFPARLSCFPLIQ 384

  Fly   416 RFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRN 480
            |||||.....::|..|..|:......|..|::..|:.::||.::.|||.::|.:.:|:|||.:|.
Zfish   385 RFGRRICQSVVLLLGGTACLIIPAIPAKYPIVVTVIAVIGKFSLAASFSIVYVYTAELYPTVVRQ 449

  Fly   481 SLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVL 537
            :.:...||..|...:|||...||..|:...|.:::.....|.|.||...|||.|..|
Zfish   450 NGVGLNSMCARVAGILAPLIGLLDVYHHAIPMIIYGSLPFVGGALTFLLPETLNTDL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	158/507 (31%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	122/383 (32%)
slc22a13b	XP_017209322.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030